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I'm well out of my comfort zone on this one, and it looks like a small homemade experiment with some charts that aren't ideal. But, well done to the authors for getting on and doing something and writing it up. It looks to me as though the impedance of a solution with a standardised number of...

They note that the non-inflammatory PASC group still had proteomic differences compared to the controls Despite what they noted about some symptom differences earlier, in the discussion they comment about how symptoms aren't good at discriminating between people in the two groups they...

I'm not up to much this afternoon, and have run out of steam to copy charts. But there do look to be some interesting findings. Have a look at the Figure 3 charts. On symptom differences:

Further on the heterogeneity of the sample, they found that the Long Covid sample divided into two clusters, one of which looked like the healthy controls (on the left in the Fig 3a chart below) and one that was almost completely different (on the right). Pink is PASC, grey is healthy controls...

Indeed, that's really disappointing. To not be anywhere matched on sex or age surely is a problem in proteomics? The PCA (Figure 1a) describes relatively little of the variance (PC1 explains 21% of the variance; PC2 explains 6% of the variance), and there's no clear separation of people with...

I agree. CoQ10 sounds like something that should help, supposedly covering the very common hand-wavey explanations of ME/CFS - inflammation and mitochondrial dysfunction. But there's no evidence that it, on average, does help in any meaningful way. People can sort out for themselves whether...

The approach to fatigue and ME/CFS specifically in Newcastle seems to be variable, it probably depends enormously on which team you are talking about. There are definitely some problematic attitudes there, and I personally doubt that Julia Newton has done much to counter those attitudes. There...

I haven't read the paper to see how strong this finding is. Could be interesting to look for these lipoglycans in people with ME/CFS, with a longitudinal analysis covering good and bad days.

What is that opinion based on? This paper, the IDEA-FAST project (which seems to have taken a broader approach to assessing the utility of wearables), or direct knowledge of what the group is doing? I assumed that this group probably played a role in NICE approving five devices for use in...

Regarding that Newcastle Hospital article Interesting that there is such as recognition of fatigue as being such a troublesome symptom. Julia Newton is part of the Newcastle-upon-Tyne NHS, she ran (runs?) the fatigue Clinic there and seems to be seen as an expert on fatigue in that region. On...

High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: randomized, phase 2, crossover trial 2022 Hansen et al This is a good recent double blinded study of CoQ10 (500mg/day) for Long Covid - they didn't find any benefit, and, remarkably, clearly said so. From...

Cells from a muscle biopsy: 19 GWI; 17 controls 14 matched pairs for a subset analysis There was some missing data - actual numbers contributing to reported means isn't reported. There were 19 different assessments made of mitochondrial function (results in Supplementary Table 1); hsCRP was...

I have only read the abstract. It's not looking very positive. There was no benefit on the primary outcome (General Self-rated Health), for either 100mg/day or 300mg/day. They did some post hoc subsetting, reporting that 100mg/day was associated with a significant benefit, in males. I don't...

https://direct.mit.edu/neco/article-abstract/26/11/2594/7999/Coenzyme-Q10-Benefits-Symptoms-in-Gulf-War?redirectedFrom=fulltext paywall I think Abstract We sought to assess whether coenzyme Q10 (CoQ10) benefits the chronic multisymptom problems that affect one-quarter to one-third of 1990–1...

Acetylcholinesterase inhibitors might be the common factor in illnesses like GWI, including in ME/CFS and chronic ciguatera. Ref #9 Golomb, B. A. et al. Coenzyme Q10 benefits symptoms in Gulf War veterans: Results of a randomized double-blind study. Neural Comput.26, 2594–2651...

Wearable technologies that monitor Parkinson’s symptoms recommended for use by NHS in England NICE recommendations I think we need to prioritise research on the use of wearables in ME/CFS clinical care. I note that Parkinsons UK funded the initial studies on the feasibility of wearables...

Thanks for the discussion @Michelle, it has helped develop my opinion. I agree. I've just posted on another thread an announcement from Parkinsons UK about a decision by NICE earlier this year to approve 5 remote monitoring devices (smart watches, ankle monitors etc) for clinical use for...

Wearable technologies that monitor Parkinson’s symptoms recommended for use by NHS in England Feb 2023 https://www.parkinsons.org.uk/news/wearable-technologies-monitor-parkinsons-symptoms-recommended-use-nhs-england "NICE have conditionally recommended 5 remote monitoring devices for...

Mānawatia a Matariki Hoping our Aotearoa New Zealand members are keeping warm and have loved ones near.

The cost of a basic consumer fitness tracker is pretty minimal (less than the cost to the government of an hour of individual CBT, I expect), and they often can run for two weeks without charging. They are much less hassle than trying to write down how much activity is done. I think they could...