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Some posts on this paper have been moved to the dedicated thread: Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder, 2023, Nagata et al

A relevant thread: Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 2012 Booth et al This refers to the Myhill-promoted Test that included cell-free DNA levels. And another: Elevated cfDNA after exercise is derived primarily from...

A thread for discussion of Cell-free DNA in general: Cell-free DNA levels

Those are massive increases in levels of cfDNA. The graded exercise test is just 12 minutes, a CPET. It's interesting that there was a lot of variation in fold change among the participants. These figures (1C and 1D) show the amount of cfDNA released by various cell types in a range of...

So, a new technique to identify the source of cell free DNA. There might be issues if the cells of people with ME/CFS that then go on to release cell free DNA are not operating normally (and so are methylated unusually), but it still sounds interesting.

That's a short half-life Perhaps it would be necessary to look for differences in cell-free DNA immediately after exercise and/or during PEM.

I see that Andy has discussed this on this thread: Elevated cfDNA after exercise is derived primarily from mature neutrophils, with a minor contribution of cardiomyocytes, 2023, Fridlich et al

I know this test was discredited, although I believe it was by Julia Newton's team. Some of her papers have been problematic and her stance on the applicability of BPS ideas to ME/CFS is well less than clear. My vague impression of the people involved in doing the Myhill-promoted test was that...

It's a good article but there's a strong message that these terms are okay for the professionals to use, it's just when amateurs start diagnosing the people around them that there are problems. I don't think the "professionals" are immune from causing harm. This reminds me of a recent post on...

There's discussion of the negative effects of increased levels of oxygen. The low oxygen environment of high altitudes seems to protect against cancers. Oxygen supplementation in the absence of evidence of hypoxia does not seem to help improve patient outcomes in stroke and heart attack. That...

Measurement of oxygen levels in cells

I wonder if a state of hypoxia, perhaps even just normal levels of hypoxia, could be the trigger for an abnormal process that results in PEM?

Research from Jordan. I can't quite work out what the Results section is saying. I don't know about the selection approach, but there's a possibility that there are some useful findings there in the text of the paper. And it's always interesting to hear views from another country about ME/CFS.

Antigen persistence in the absence of viral persistence

There's claims of higher levels of inflammatory molecules e.g. CRP in Long Covid, to fit with their overall story of inflammation causing prolonged symptoms, but I think findings have been variable and inconclusive. Ebola - Associations between antibody Fc-mediated effector functions and...

https://www.sciencedirect.com/science/article/pii/S0952791522000759?via%3Dihub Highlights Post-acute sequelae of SARS-CoV-2 (PASC) are associated with persistent inflammation. The antigens or other immune stimuli driving PASC are still unclear. PASC severity and duration is reduced by...

That must be Professor Andrew Lloyd. That list of conflicts is woefully inadequate. He runs a clinic that treats people with CFS using CBT and GET: https://www.unsw.edu.au/staff/andrew-lloyd He was a co-author of an incredibly poorly done (NHMRC funded) paper re-analysing the Dubbo study...

Great quotes on FND, thanks Baseit. The use of 'functional' as a smokescreen, a palatable way of saying 'psychogenic', is very clear from the quotes in the first item.

It feels as though this label could well be the price patients pay for having a problem that the doctor doesn't know how to fix, and for having the temerity to turn up in a clinic, wanting an answer. And, when there isn't a real answer and they are, instead, told that if they thought...