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Yes. I'd like to see a bit more about data security. The link for Privacy Policy goes to Yuzu labs. Yuzu seems to be a small San Francisco based company - perhaps only 2 employees? They run Study Pages and promise to keep data secure, but their customer is, in this case, OMF. Yuzu says: So...

The Solve You and ME Registry also accepts people in Australia.

Putrino is a staunch advocate for people with Long Covid. But he talks about "settled science" while listing a whole lot of findings on the pathology of Long Covid that are far from settled. It's a problem we have discussed often here - holding up preliminary findings of biological pathology to...

I agree. The more you look, the more there are many reports, not at all flaky, of latent infections that cause problems some time down the track. It may not be the answer to ME/CFS, although it could well be. But certainly medicine should be giving these a lot more attention. And, I also...

Dr Nath was asked about the criteria used in the intramural study, the inference being that the MEICC criteria should have been used, and that there is too much focus on the one symptom of PEM. Nath replied that they applied several different criteria and that they were as sure as they could be...

Dr Avik Roy and Dr Gunnar Gottschalk NINDS has just issued a research award for their work on ATG13 [so perhaps that tells us something about what the intramural study found?] they collaborate with Dan Peterson at Incline Village and are based at the University of Wisconsin. The lab there at...

I did make the webinar. 204 attendees, it will be recorded. Some notes: Koroshetz had a conflict and couldn't make the call. Vicky Whittemore: talking about the trans ME/CFS working group. Making a Roadmap, to assess what we know and don't know. Considerable efforts have been made to include...

Another reminder for the call. It's on at 4 am where I am, so I probably won't make it, but would love to hear the news. Here's the link for the recent Avik Roy and Gunnar Gottschalk paper, in case you want to refresh your memory prior to the call. Elevated ATG13 in serum of pwME stimulates...

High levels of pro-inflammatory SARS-CoV-2-specific biomarkers revealed by in vitro whole blood cytokine release assay (CRA)... 2023 Gomes et al This other small study for example found that people who had had Covid, including those with persisting symptoms, had higher IL-8 levels than healthy...

Ok, just to make this thread completely confusing: It turns out that there's a 2019 paper by Sweetman that mention G3BP2 (note the 2, not 1) Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome, 2019, Sweetman et...

I made this thread mostly because I thought the protein that seemed to be closely tied to viral persistence was the same as the protein that was found to be significantly reduced in ME/CFS immune cells in the Sweetman paper. But they aren't the same proteins. RAS GTPase-activating protein 1 is...

Reading the discussion in the paper linked to in the first post of this thread, it sounds as though different viruses employ different strategies in relation to G3BP1 and stress granules. Combine that with different host genetics and environment, and that could explain the seemingly different...

Different viruses have different impacts on stress granule formation, some increasing it, some decreasing it. So there's a delay of about 24 hours between the stress on the cell and the up regulation of the viral transcription. (Perhaps that fits with PEM?) I think the authors are suggesting...

There's this study GTPase-activating protein-binding protein 1 (G3BP1) plays an antiviral role against porcine epidemic diarrhea virus, 2019, Pandey et al It's suggesting that reduced G3BP1 reduces stress granule formation and increases the success of a virus in replicating in pigs...

Edit - the RAS GTPase-activating protein 1 and the RAS GTPase-activating protein-binding protein 1 are fact different, despite the very similar names. So, ignore this post. See later post. [Googling to see if anyone has reported on Ras GTPase activating protein-binding protein in ME/CFS, I...

I've made as thread to discuss Ras GTP-ase activating protein-binding protein 1 here: Ras GTP-ase-activating protein-binding protein 1

Some general discussion about calcium signalling has been moved here: Calcium signalling; calcium channels

Ras GTPase activating protein binding protein 1 This molecule was mentioned in a paper - levels of the molecule were used as a measure of cell stress (higher levels correlated with higher cell stress): Molecular mechanisms of stress-induced reactivation in mumps virus condensates, 2023, Xiaojie...

Yes. Two types of chemical stress, and heat stress. The paper has links to detailed descriptions of methods.

Viral replication and release are accelerated by stress I marvel at the techniques. There's a protein (RasGTPase protein-binding protein) that is claimed to be a measure of cellular stress. And fluorescent markers of both viral N protein and viral RNA. They have cells infected with the...