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Viral factories Membrane-less inclusions in cells that can be seen with electron microscopy, containing viral genomes and replication machinery. Graphical abstract

German research Thanks for posting @Mij. If I had to pick one theory on the cause of ME/CFS, I think it would probably be something to do with reactivations of pathogens that have been sitting latent in cells. I'm only a few paragraphs into the paper, but I think this is looking to be worth...

I wonder if the slowness to bring the results into the public is because of a desire to get all the ducks in a row, to make sure things are unassailable so that people within the NIH and in politics who don't believe in ME/CFS as a biological illness can't easily attack it? A sort of going slow...

I wondered about that, but Figure 1A plots the individual results for the healthy controls, and they look to be quite tightly clustered.

Walitt's views were pretty bad, and, extraordinarily, enough people with decision-making power in the NIH thought that Edward Shorter's extremely misogynistic views about CFS were interesting enough to have him come to the NIH during the ME/CFS study. So, I think some concern is warranted...

Thanks @CRG! Dotted line is the healthy control mean plus 2 standard deviations. The chart indicates that there is a clear increase in the level of anti-CHRM1 antibodies in about half the CFS participants, but not in healthy controls. It looks pretty nice. "cpm" is counts per minute...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409949/ Gambierdiscus species are the producers of the marine toxins ciguatoxins and maitotoxins which cause worldwide human intoxications recognized as Ciguatera Fish Poisoning. A deep chemical investigation of a cultured strain of G. belizeanus...

From an information sheet about Ciguatera https://www.whoi.edu/science/B/redtide/illness/ciguatera_fish_poisoning.html One of the toxins present in varying amounts in Ciguatera fish poisoning, that we haven't discussed before is maitotoxin. It increases calcium ion influx through excitable...

A reminder about this call - it will be interesting to hear what the NIH is saying on 'updates on ME/CFS-related research activities'. Note the need to register in advance.

An old study that has been included in a list of studies finding issues with G protein-coupled receptors. https://pubmed.ncbi.nlm.nih.gov/12851722/. Paywall Abstract The disturbance of the central nervous system and immunological abnormalities have been suggested in patients with chronic...

My brain has moved to treacle mode. Yeah, I edited out that sentence about them knowing the concentration of the 7S DNA, as I wasn't sure.

I'm not surprised that you say this, as, the study looked pretty patchy to even me, who doesn't know the technicalities. They may have standardised the amount of DNA applied to each sample of microglia. But yes, there's quite a lot that they have not told us.

[Crossposted] I've got to stop, I'll have to come back to this. The last figure is Figure 3 which gives the amount of IL-1b produced by microglia cells exposed to the exosomes from healthy and ME/CFS people. These are the pooled samples. This study isn't feeling very solid. There might be...

So, serum for an unknown number of people with ME/CFS before and after exercise and serum for an unknown number of healthy controls, presumably just before exercise. The order in these charts is Healthy Controls: ME/CFS before exercise: ME/CFS after exercise Figure 1b shows that total exosome...

Theoharis C Theoharides; Irene Tsilioni - Tufts University school of Medicine Benjamin Natelson - Icahn School of /medicine at Mt Sinai Funded in part by the Ramsay award from the Solve Me/CFS Foundation The writing is accessible. The small size of the study is noted as a limitation. The...

Rapid responses to the paper are possible, if anyone has the energy and inclination to quote some of the papers that have found significant numbers of Long covid people meet ME/CFS criteria. We have a tag "lc=me/cfs" that can be put on papers that assess LC patients against ME/CFS criteria...

Yes, that's interesting. It's a problem. Reading about that recent COFFI meeting where the BPS people were wanting to attack these ideas of extremely low recovery rates in ME/CFS, I do think we need to improve in our educational materials and things like the CCC. It's a more complicated story...

Oh, yes, that would be great. I could definitely see David on the international literary event circuit too - I reckon there'd be a lot of interest.

Are they seriously going to cold call people, targeting migrants who may or may not have good German language skills, with the aim of getting 2400 people to tell them about their bowel function? And quiz them about their health literacy, their personal experiences with their IBS, including the...

"Persistent somatic symptoms - parameters of risk" PSS-POR :whistle: