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Background on CD169+ from Functions of CD169 positive macrophages in human diseases (Review), 2021

It's great that this study was very selective with the group with post-acute covid-19 symptoms i.e. They didn't just use a group of people with Long Covid, with that vaguely defined as at least one ongoing symptom, which could be anything as diverse as loss of smell, poorer lung function and...

New abstract Myalgic encephalomyelitis, ME, previously also known as chronic fatigue syndrome (CFS) is a heterogeneous, debilitating syndrome of unknown etiology responsible for long-lasting disability in millions of patients worldwide. The most well-known symptom of ME is post-exertional...

More on the consultation process for the "Examining the Working Definition for Long COVID" here: USA: 'Examining the Working Definition for Long COVID' consultation 2023

The study reports that 59% of depressed people had their depression improve in at least a minor way, over the 4 years after talking therapies. And yet, 53% of depressed adults who receive no treatment have been reported as showing improvement within 12 months. I haven't checked out that...

That headline is true - people have linked talking therapies with cardiovascular disease. However, it's also very misleading - it makes only just a tiny bit more sense than "Cheese linked with the composition of the moon". There were no controls - everyone in the 636,955 person sample...

We have an In Memory thread here Dr Jonathan Kerr

While I have reservations about NCNED (and awe at their ongoing ability to pull in funding), I think the Australia Rickettsial Research Laboratory and specifically the main person there, Professor Stephen Graves, is good, scientifically and for their concern about people with ME/CFS. It's a bit...

A 2023 study failed to replicate the findings of the 2021 study: Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia, 2023, Sara Cavaria et al

One more thing: This study failed to replicate a 2021 study on the transfer of pain behaviour to mice via IgG from people with fibromyalgia. That study made quite a splash at the time. Forum thread on that study here: Passive transfer of fibromyalgia symptoms from patients to mice, 2021...

Well, I didn't see even an acknowledgement of the potential problem of human neutrophils in mice in the paper. The charts seem to make a good story, but there is a credibility problem.

Ha. I wondered whether human neutrophils would work in mice, it seemed a bit amazing. I haven't read the discussion of this paper yet (or much of the Method - which is at the end of the paper. Surely, they will address that issue, it's pretty fundamental. Not to minimise the impact of these...

For sure, it's a bad sign when the introduction makes claims that aren't supported by the references given for them. But, I think I said just the other day, it seems to happen in most papers. It's the last section that I find most interesting. The healthy mice were treated identically, except...

Neutrophils Derived from Patients with Fibromyalgia Syndrome Induce Mechanical Hypersensitivity in Mice The researchers then took neutrophils from people diagnosed with fibromyalgia (9) and healthy controls (5), and injected them into new healthy mice (4 mice for each person). So, this is the...

Neutrophils Derived from Mice with Chronic Widespread Pain Infiltrate Sensory Ganglia Somata? Plural of soma - the body of the neuron (and a few other cell types). So, they found neutrophils had infiltrated the somata of the dorsal root ganglion in the mice that had had two injections of...

I'm not surprised. I can't recall any reliable reports of elevated cytokines in ME/CFS or fibromyalgia, although perhaps there are some. I'm not sure, has it been known before that neutrophils are associated with peripheral pain? And that removing them seems to prevent the pain? That bit...

Circulating Neutrophils Are Essential for the Development of Hypersensitivity in a Mouse Model of Chronic Widespread Pain So, now the researchers wanted to find out what is causing this sensitivity of the nerves. This works was done in 4 control and 4 primed mice. They transferred blood...

In vivo electrophysiology The mice were anaesthetised,and the spinal cord exposed. Then the researchers applied stimuli (pressure and heat/cold) to the hind paw and measured the evoked activity of neurons. These measurements were done by an experimenter blind to which sort of mouse they were...

Persistent Hypersensitivity in a Mouse Model of Chronic Widespread Pain So, a model of chronic widespread pain? What this seems to be is two injections of an acute inflammatory stimulus into muscle, 4 days apart - thus creating the 'Primed Mice' The 'Control Mice' only had one injection. 7...

Some background information from the introduction that sets up their study - could be worth checking the references out: (that's not about neutrophils - but might worth reading about. Have we heard about mitochondrial transfer?) (Neutrophils are a type of white blood cell, as are...