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I get that. Most providers of knowledge content pay the people who produce content (e.g. journalists) and those who improve it and check it (editors and content checkers). Scientists producing papers shouldn't have to pay to get their results out into the world, and possibly should actually be...

Sounds a little like Paul Garner's superpower in overcoming Long Covid within a year. I think it might be the BPS superpower of attributing things that would happen anyway to one's own moral superiority.

Thanks for identifying some key areas to look at @Ravn. I did make some comments a while back, but I should go in and give it another go. It's a bit of a random approach to consultation, but I expect the content will be considered, at the very least by political parties wanting to get a sense...

Yes. I guess I was thinking of this as a potential source of misdiagnoses. So, there may not be enough people with this particular problem misdiagnosed as ME/CFS to get about the threshold for significance. But, DecodeME might find a handful of people with the functionally impaired variants...

That trial is the Castro-Marrero one; forum thread here: Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related QoL in ... ME/CFS, 2021, Castro-Marrero et al.']Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and...

It's baked in, this inability to differentiate association with causation.

CoQ10 - Coenzyme Q10 Here's our CoQ10 discussion thread. I'm not aware of any credible trial identifying CoQ10 as useful in ME/CFS and do know of some that suggest that it probably isn't. But, interesting to see that defects in the COQ2 gene are associated with that condition 'familial...

One thing I'm not sure about is the difference between lactate in peripheral blood from fingerpricks and lactate as measured by a catheter as per that study I linked to above. Is there any reason that the different sources/methods might tell a different story? There is that one 2022 study...

If ever anyone comes across health-related research recently approved in Aotearoa New Zealand that you think is unethical, perhaps due to risks to participants or due to its lack of scientific merit, please do send me a message.

I was a member of the same college! I can confirm, members do not all agree with Sharpe. Not sure about fellows.

It sounds as though elderly and other very vulnerable people were shielded early on, so a lot of the people who did get Covid-19 early on would have been young people at low risk of death. And a lot of the people who both got covid-19 early on and were tested probably were young medical...

Forum thread here for this Ref #7: Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome, 2022, de Boer et al It found higher lactate in people with post-acute COVID-19, even with no co-morbidities, using catheters during...

Just on the lactate question: Figure 1B. From the left: PASC with comorbidities PASC without comorbidities Metabolic syndrome Healthy, moderately active Measured using a catheter during CPET.

In that Resilience diagram, "Behavioural Activation" features prominently - helping with 'good routines', 'purposeful activity', 'keep active and involved'. Then there's Mindfulness; Problem Solving; Managing worry; good sleep habits; contacting'Talkplus'. I'm pretty sure that CBT fits all...

Symptoms like this? Symptoms that sound a lot like a lot of Long Covid? I agree that you'd think it would have been noticed and raised questions. But... I haven't read this paper, or looked at the references that the authors cite to support their claim of

It is really gratifying to see such co-ordinated and generally well-conceived push-back against the CLoCK Study. Well done to the people involved. I hope that they will keep pushing.

One of the biggest problems is that the CLoCK study is going to say 'oh, these symptoms are very common. Look, the children who weren't infected with Covid (as evidenced by a negative test) have just the same sort of symptoms. So, Long Covid isn't a thing.' So, again, there's trouble with a...

What a mess of buck-passing. I don't understand why the research ethics committee that approved the research (Yorkshire/Humber/South Yorkshire REC) isn't answering the letter of complaint. I'm not sure what 'sponsor' means, but it sounds a lot like someone marking their own homework. How can...

Yes, particularly in a story about mothers and daughters. 'what's gone on in your environment' makes it too easy to start blaming mothers.