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There's a 6 minute video, and I initially thought, great, I need pictures of this. But, I didn't find it very helpful and I definitely don't recommend watching it if you are not feeling well. There's background jazz playing throughout, people seem to have found the places to be recorded in...

Extracardiac Abnormalities of Preload Reserve, Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease, 2021 I didn't find it an easy read, but there are interesting points. Pre-load failure can be caused by blocked...

Prolonged grief disorder in section II of DSM-5: a commentary, 2020 DSM-5 PGD is present when, after the death of someone close at least 12 months earlier (Criterion A), a person experiences intense yearning or preoccupation (Criterion B), plus at least 3 of 8 symptoms of identity disruption...

Yes. I think it's entirely reasonable for a GP to respond to the scenario of a patient who didn't respond to treatment with anti-depressant drugs by considering the possibility that the person might be sad, rather than medically ill. Considering the possibility that they might have been...

On the replication of the finding of "pre-load failure", that surely is something that needs to be done by an independent team as soon as possible? Do we know of any study underway or planned? Something like that would, I think, be a good use of some of the AUD50 million allocated by the...

There was a mention of a citrate synthase test, supposedly showing that 10 out of 11 patients had mitochondrial dysfunction. My natural set point is skepticism. Does anyone have more details about that?

The paper on mestinon and the graphs shown (at 17 minutes in the talk) related to an acute dosing. The patient did an iCPET, and then rested with the lines still in, and then exercised again 90 minutes later, with or without having had a dose of mestinon in the interim. The charts suggested a...

Links to discussion about presentations made at the conference: (these links are also in the first post of this thread) Some posts on this thread have been moved to the threads indicated, to consolidate the discussion. David Systrom, researcher, Brigham and Women's Hospital, USA IIMEC 2023...

Chemicals in muscle, change with exercise or PEM I think there is potential in using the technology on muscles, to identify abnormal changes with exercise or during PEM. This trial of a potential treatment actually used the levels of a molecule in muscle as determined by MRS as an objective...

This is interesting. I have been wondering if we have any studies that have used magnetic resonance spectroscopy (or any spectroscopy) to evaluate changes in biochemistry with PEM, or with exercise. I haven't looked at the study to see what made them think phosphocreatine in particular was the...

Just so we are clear on the difference between MRI (Magnetic Resonance Imaging) and MRS (Magnetic Resonance Spectroscopy) (obviously it can be applied to more than just tumours in the brain) "Magnetic Resonance (MR) spectroscopy is a noninvasive diagnostic test for measuring biochemical changes...

Chemicals in the brain A paper with some problems: Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla, 2021, Godlewska et al Jarred Younger looked at brain metabolites and temperature Evidence of widespread metabolite...

Brain temperature Paper here used magnetic resonance spectroscopy to identify temperature differences Abnormal immune system response in the brain of women with Fibromyalgia after experimental endotoxin challenge 2023 Mueller, Younger et al A daily temperature rhythm in the human brain predicts...

Mitochondrial dysfunction Paper here on mitochondrial dysfunction with magnetic resonance spectroscopy: A case of mitochondrial myopathy, lactic acidosis and complex I deficiency, 1990, L Bet et al

Thanks Jonathan. Perhaps not if it was a transient phenomenon, as you say? I doubt much magnetic resonance spectroscopy or imaging has been done during PEM. (?) Maybe it's worth doing magnetic resonance spectroscopy on muscles before and during PEM? There has to be some reason for the...

Do we know this? e.g. in tender lymph glands during PEM? in painful muscles during PEM? It sounds then as though finding t-cells in tissue might be the thing to look for, rather than t-cell diversity in blood?

The definition of Long COVID is pretty weak - as when "at least one symptom lasted for more than 4 weeks following the first COVID-19 infection". There's no requirement for the symptom to cause significant impairment. It also wouldn't capture any Long Covid after subsequent infections. There's...

A number of posts have been moved to a new thread: Clinical support and encouragement versus manipulation (includes motivational interviewing)

This is the reference for the suggestion that TCR clonal diversity in MS is in tissues, not blood This is making my head explode a bit. Public and private clones? There's this paper that might shed some light on that: Public and private human T-cell clones respond differentially to HCMV...