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A Beighton score of 3/9 is normal. I'm not a physiotherapist, and I'm not sure what is being said about these other tests. But, as an example, that elbow extension test isn't saying that the man's range of motion at the elbow was 130 or 140 degrees - when, give or take a few degrees, 180...

That bolded sentence required a bit more of an explanation, I think. On the one hand, the ME/CFS patients have higher than normal range of motion in joints, but some of the joints have lower than normal range of motion? and both things are indicative of ME/CFS pathology?

Here's the thread on that earlier case series Petracek, L.S.; Suskauer, S.J.; Vickers, R.F.; Patel, N.R.; Violand, R.L.; Swope, R.L.; Rowe, P.C. Adolescent and Young Adult ME/CFS After Confirmed or Probable COVID-19 2021 I wonder if we are going to see similarly detailed case studies for the...

This paper cites Circulatory and maturation kinetics of human monocyte subsets in vivo, 2017, Tak et al That paper, while acknowledging that these ideas need further testing, suggest that the classical monocytes come out of the bone marrow and last about 2.5 days in the blood. About 90% turn...

Among the topics to be covered - some slightly concerning ones there:

Noting that this announcement of NIH funding of the Cornell team has been merged into this thread, in case you missed it

I think this abstract rather obscures the significant finding of brain infection in both young healthy and older diabetic monkeys. We've seen brain infection also reported from postmortem studies of human brains. This study is explained in this readable article: SARS-CoV-2 causes neuronal...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554328/ Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications in some patients. However, it is still under debate whether...

Common symptoms include: Blurry vision or blindness in one or both eyes Weakness or paralysis in the legs or arms Painful spasms Numbness or loss of sensation throughout the body Persistent nausea Uncontrollable vomiting Persistent hiccups Bladder or bowel dysfunction Sleeping problems

The research priorities from the website Muscle tissue Immune Dsyregulation in Classical Monocytes and Platelets I note the focus on classical monocytes - I think non-classical monocytes were looking interesting in someone's study but, it sounds as though the Cornell team are following a...

That chart shows increased drug prescription rates in people infected with covid-19 in the 30 to 180 days after the acute infection. The top blue section is for neurological drugs - so that is where the anti-depressants would show up if there was a big spike in them. There is some increase...

I'll just add this, to explain those two codes on the last line of the chart excerpt above. U099 - post-COVID-19 condition, unspecified, and B948 - sequelae of other infection and parasitic diseases These probably overlap with ME/CFS. Edit to add - supplementary Table 2 shows which codes they...

Here's just an example of the data presentation - the charts are very clear throughout, and well worth a look through. These excerpts are for Adjusted excess burden (numbers per 1000), just for the New York sample: This is a massive sample, so it carries some weight. Diagnoses were added...

Even with that important proviso, I thought this study was well done and made for very interesting reading. The differences between the two data sets, Florida and New York, are really remarkable. There was a lower incidence of PASC associated conditions in Florida and a much smaller range...

Very nice @Three Chord Monty Actually Creed found that, in the case of the people who had no existing fatigue or CFS at baseline (124,000 people), " psychiatric disorders" were not associated with the onset of CFS during the next 2 years or so* (292 people). Therefore, this study does not...

True. In this study, the data is from self-reporting by the patient, as well as an interview at baseline to supposedly diagnose psychiatric disorders. The surprising thing here is that the study failed to find any predictive power of psychiatric disorders at baseline for the onset of...

Combination of whole body cryotherapy with static stretching ... reduces fatigue and improves functioning of the [ANS] in CFS, 2022, Kujawski et al There's an opportunity to talk with Polish ME/CFS researchers on 14 April 2023, specifically about the linked research; more information at that link.

Valid points. But, at the same time, lots of scarce health service money is being wasted offering psychotherapy to people with ME/CFS who really don't need it and who actually might end up being harmed. I suspect the cost of those services way outweighs the amount of money being spent on...

And yet a lot of them are very happy about it. Many of them genuinely seem to believe this stuff - acupuncture, mindfulness as cure, reiki. And whether they believe it or not, it is a convenient way for them to get rid of a patient. When one specialist had exhausted the things she could think...