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Figure 1 is below, for CD8+ chains with data for each group in a different colour. It is noted that the outliers out to the right with higher diversity are explained by the participants being of younger age. Because it wasn't possible to get enough ME severe samples in the target are range of...

Samples covering mild and severe ME/CFS, MS and healthy controls, with the ME/CFS samples probably as well-characterised as in any study. Cytomegalovirus seropositivity didn't differ by group. It's important to note that this study looked at the diversity of T- cell receptors. There are...

This is my naive understanding, there will be members who can correct any mistakes: This paper is looking at T-cells sharing receptors with sequences that bind to particular antigens. They say this increase from production of such T-cells in the thymus, or from clonal expansion, where a T-cell...

There is a woman in my region who had a diagnosis of ME/CFS for 20 years before being diagnosed with MS. I don't know her personally, so can't ask her questions about her illness in the early years, to try to understand if she really had ME/CFS. But it does underline the point that if a person...

The RNZ article is very helpful. The link is on the thread that Trish linked above, but added here also for convenience. https://www.rnz.co.nz/national/programmes/saturday/audio/2018899512/prof-danny-altmann-the-burden-of-long-covid Professor Danny Altmann clearly could make a useful...

Yeah, my view of the diagnosis involved swear words. I guess it's good that someone thought to ask, it's just a shame that the asking is after the diagnosis was included in the DSM-5-TR.

I saw this today: (United Kingdom) Profiling the response to exercise in Long COVID patients to inform novel rehabilitation guidelines, recruiting, Faghy and Bewick Patient Information Sheet...

https://www.nature.com/articles/d41586-023-02345-7 A link for people who can't access the Times article.

Yes. I should have said, it's great that the researchers are aware of PEM, and are investigating it with CPETs. And it sounds as though they may not even ask participants to go to VO2 max. It is indeed just the concern that findings might be weaponised - I can't think how, but I'm sure there...

I thought this was interesting.

The Patient Information Sheet does not say that any psychological data will be gathered - so hopefully they won't be doing that. What are people's views on whether people who participate should get copies of their personal data e.g. the results of the CPETS? As well as the data being of...

The Patient Information Sheet doesn't look too bad. There's a lot of talk about recovery, as if it's a foregone conclusion that everyone will recover. I note that there doesn't seem to be any involvement of people with Long Covid, no Patient Advisory Group, no association with a Long Covid...

It's a bit surprising to have Gilead fund this study, but there's no obvious problem with the funding.

The EMG stuff was compared against previously derived values for people of the same age and sex. So, I think when they say a result is abnormal, they have some basis for saying that. The histology is a bit beyond me. They are saying that in the images of nerve terminals that they captured...

Basal lamina? Pyridostigmine? (Mestinon) The authors acknowledge the small number of biopsies.

*referred for electromyography (EMG) examination due to severely affected and non-improving daily function, as well as physical/muscular exhaustion, myalgia or reduced force. 76% of patients female 16% have abnormal levels of creatine kinase (indicates muscle damage) 8% have abnormal levels of...

qEMG - quantitative electromyography A review of clinical quantitative electromyography, 2010 "Information regarding the morphology of motor unit potentials (MUPs) and motor unit firing patterns can be used to help diagnose, treat, and manage neuromuscular disorders. In a conventional...

I thought Altmann was good. He came across as credible and measured, and I think he helped the causes of Long Covid, and ME/CFS. He didn't answer a question about post-exertional malaise well. He explained it was different from just tiredness after exertion, that young people who were very...

Abstract Background: Post-COVID Clinics were recommended for patients with persistent symptoms following COVID-19, but no specific tests were suggested for evaluation. This study aimed to present a post-COVID clinic patient cohort and evaluate the use of a post-COVID symptom questionnaire (PCQ)...

Forum threads on these three previous papers by the same Danish team: Myopathic changes in patients with long-term fatigue after COVID-19, 2021, Agergaard et al Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology, 2022, Hejbøl et al...