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Ah, this is interesting: Neil O'Connor, the first author

Thanks for posting this @EndME. I'd like to use it in advocacy as it seems pretty compelling. What do we know about the authors? Do they have a track record of good, reliable work?

See this study: Trials we cannot trust: investigating their impact on systematic reviews and clinical guidelines in spinal pain, 2023, O'connell et al It's pretty clear there is virtually no evidence to support the use of CBT for back pain.

The Canterbury Health Pathways team has let me know that they will inform teams in other regions about the webinar. Probably wouldn't hurt to enquire if you live in a region where HP is used.

I guess, but all science has similar problems. As this paper says" And meta-analyses can compound the bias. I think it is possible to do a review with rigour, and for your assumptions to be laid out so clearly that others can challenge them, and conduct sensitivity analyses to see if assuming...

I have been surprised to find out how variable MS lesions are over time - they seem to come and go, often quite rapidly. We have a discussion about some research on that somewhere on the forum, but I haven't found it yet. I think that might explain why some people take a long time to be...

Just thinking about the blinding - that will be difficult. It will be fairly obvious if someone is receiving the painkiller, so, if they don't have treatment arms with each drug individually and combined, then I don't think the blinding will be effective. There will be some people who get...

Welcome to the forum @Frenchguy, I'm sorry to hear about the extraordinary challenges you have been facing. Tagging @Jonathan Edwards

It's terrific news - the finding of possibilities, and the fact that the company is discussing things with DecodeME.

Not surprising that celecoxib would help pain. I'm skeptical of valacyclovir making a significant difference. It's been trialled in ME/CFS before. Forum thread here:Antivirals as ME/CFS or Long Covid treatments (e.g. valacyclovir, valgancyclovir) Still, it will be interesting to see the...

I struggled to get much out of this paper that is relevant to Long Covid. Perhaps the sample that was followed for months wasn't big enough to have sufficient Long covid participants. It looks as though people with persistent fatigue are most likely to have initial features consistent with...

On the Long Covid analysis:

I agree with this on Moreau's last slide, even with the exclamation mark. Unfortunately I didn't find this presentation to be part of the roadmap. There may be some true findings in there, but the presentation was not very convincing. For example, Slide 10 15 mins Random Forest Classes with...

I don't think GRADE has to fail on this - it depends entirely on how it is used. Quoting my comment from elsewhere: So, if a trial is completely unreliable, for example the researcher sat at a table and just made up the data, it can and should be excluded from an analysis. But, a trial...

Well, not to get ahead of ourselves, it's just that those charts in Maureen's presentation looked compelling compared to the usual equivocal charts we see, and I trust her team's work more than many others. We may need to find the pathogens, or at least know what is triggering immunological...

Probably the latter, and, in any case, the processes would be very much related. For sure, something starts to happen after exertion. But, there must be an additional thing, either a molecule gets to a level that can't be neutralised and starts to cause new symptoms, or that level of molecule...

Yes, this. I'm not objecting to the use of the cuff, and monitoring the response to it 90 minutes later. It's the suggestion that this is measuring PEM. Yes, it's semantics, but crucial semantics. I think malaise needs to be present for something to be post-exertional malaise. A response to...

The sex ratios are not consistent in the groups (lower percentage of men in ME/CFS group), and they seem to have found very different levels of ferritin in females in teh different groups. See Figure 3. I can't look at this carefully right now, I might come back to it, or someone else could...