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Apologies for my black humour this evening and no disrespect meant. But a strongly decreased respiratory rate rather reliably goes with the territory of being a non-survivor.

My comment about shell shock was just in relation to the mention of physical manifestations of PTSD. I suspect a lot of what was termed 'neurasthenia' after World War 1 had a fair bit to do with brain damage. I agree that 'faking it to avoid being sent back to near certain death' could...

(I don't know what article is being discussed here.) I've read some of my grandfather's diaries, including one covering time in the Somme in WW1. He didn't write about anything that sounds like conversion disorder, but he did comment a few times about how shells would cause outcomes that...

It might. The paper goes through the various calcium channels and pumps. Transient Receptor Potential (TRP) channels are one sort of channel.

Indeed. And this is being suggested to doctors as appropriate things to focus on with their ME/CFS patients. There's a serious disconnect there. Music, meditation and yoga sounds like a pleasant holiday. For people only mildly affected, attention to well-being is much more likely to be...

I was wondering whether it's possible to easily differentiate viral miRNA from host miRNA, even if a particular viral miRNA is doing the same job as the host miRNA. It sounds as though it might be possible.?

This paper has some of the same authors as for this recently posted paper:Viral miRNA regulation of host gene expression, 2023, Diggins and Hancock So, we know there could be viruses hanging out in bone marrow producing infected cells. Perhaps either the progenitor cells or the infected cells...

Lindsey B. Crawford, a ,* Nicole L. Diggins, a Patrizia Caposio, a and Meaghan H. Hancock a Abstract Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ transplant, as well as the leading...

Interesting. Having got my head around micro-RNAs made by the host in order to adjust gene expression, here we have viruses making micro-RNAs that can hijack the host's gene expression, in order to help the viruses survive and/or replicate. And we've seen elsewhere where a cell infected with...

That video (which I agree is really awful in places) makes me very concerned about who they will have evaluating the research proposals. Does anyone know?I suspect the panel will involve Dr Vallings - she's the doctor who recommends singing in the shower in order to tone up the vagal nerve...

Interesting that the paper also mentions mir-142 - that was also found to be increased in ME/CFS by the Brenu paper: In both cases, up-regulation of the two types of microRNA (as found in that 2014 ME/CFS study) might provide protection against a pathogen. It would be great to have...

I was looking for something else and noticed that the miRNA found to be decreased during Coxiella burnetii infection was mir-143-3p. We've seen this miRNA before, in the 2014 Brenu paper on miRNA in ME/CFS. That paper identified three mRNA increased in ME/CFS, one of which was mir-143-3p...

Abstract MicroRNAs (miRNAs), a class of small noncoding RNAs, are critical to gene regulation in eukaryotes. They are involved in modulating a variety of physiological processes, including the host response to intracellular infections. Little is known about miRNA functions during infection by...

It seems that viruses in general target host cell calcium channels in various ways - see here: Host Calcium Channels and Pumps in Viral Infections, 2020, Chen et al

It seems that this disruption of cell's calcium processes is common in viruses. A recent SARS-CoV-2 study noted that the virus affects calcium signalling in endothelial cells. Endothelial cells, especially in the muscles and brain, can live a long time. A lot of ME/CFS symptoms could be...

Host Calcium Channels and Pumps in Viral Infections Xingjuan Chen,1,2 Ruiyuan Cao,2,* and Wu Zhong2,* Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to modulate...

Interesting, SNT, especially in the context of the NCNED suggestions of TRP channels having problems in ME/CFS and the findings and symptoms of ME/CFS that seem to fit with endothelial dysfunction. I haven't read this study yet. From the abstract, it looks as though they are suggesting that...

Welcome to the forum @Sparkly Unicorn. We have the following threads that might be of interest: Post mortem tissue donation and autopsies (Members Only) UK brain banks that accept ME/CFS donors Considerations in establishing a post-mortem brain and tissue bank for the study of ME/CFS: a...

Link to the bio-impedance paper @Creekside mentioned: Bioimpedance spectroscopy characterization of osmotic stress processes in MECFS blood samples, 2023 Fernandez et al

Sure, but it's not the patient who is benefitting. "REAL" - right up there in a long line of acronyms subverting the usual meaning of words e.g. PACE, RECOVER, FINE