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James Baraniuk, Kiran Thapaliya, Maira Inderyas, Zack Shan, Leighton Barnden Noting that this is part of what seems to be an extended collaboration between Baraniuk and the two Queensland researchers, Zack Shan and Leighton Barnden. Shan and Barnden have done some solid work in neuroimaging in...

Rather than try to split off the discussion about CRP unrelated to Younger's videos, we have made a new thread looking at the evidence for higher levels of CRP in ME/CFS, with a poll, here: C-reactive protein, CRP Some of the key points from this discussion have or will be copied to that thread.

That's me done for the moment, but hopefully I or other people can have a look at the other evidence we have on CRP levels in ME/CFS and related diseases. I think the conclusion I came to for the 2017 review may apply to a number of the studies.

What do studies in ME/CFS and related diseases tell us? Association between C-reactive protein and chronic fatigue syndrome: a meta-analysis, 2017, Wang et al This review found 7 studies. Selection criteria of participants looks to be loose, which is a problem. (4+4=7 is due to the Sulheim...

What does CRP do? CRP is found in blood plasma and produced by the liver, is often said to be a marker of inflammation. It activates the complement system. Wikipedia says But, as with most things, it is more complicated than that, for example:

CRP measurement First some background on the measurement from some of the discussions. Levels are often reported in mg/L. Sometimes levels are reported in mg/dL - to convert to mg/L, multiply by 10. HS-CRP is high sensitivity CRP, obtained by a test that can accurately identify low levels. I...

We've discussed CRP on a number of threads. There are some hints of mildly raised CRP in ME/CFS and some suggestion that levels may track with fluctuations of illness severity. But, there are a lot of confounding factors. I'm going to link some of the papers and discussions here. When...

Prevalence of CFS and its related factors in covid- 19 patients discharged from at northwest of Iran hospitals in 2022, 2024, Arman Alizadeh et al A paper suggesting that knowledge about ME/CFS in Iran is currently very poor.

I'm surprised we don't yet have a regional thread for the Middle East as we have seen some ME/CFS and Long Covid papers out of this region. The MENA country grouping seems to be often used, ie from the World Bank definition: six Gulf Cooperation Council (GCC) members (Bahrain, Kuwait, Oman...

I sincerely do not understand how people, who come across as well-meaning, can produce such a problematic paper with so many errors in internal inconsistencies.

Conclusion Heaven help the people of Northwest Iran if this paper is an indication of the quality of thinking that will go into the creation of programs to support long-term Covid-19 patients. I'm sorry to be so blunt, but the paper is terrible. I appreciate the concern for patients that does...

Ok, the discussion They say that this is different to another study that found fatigue was the most reported symptom. But, as I noted, this is ridiculous, because there was no accounting for pre-Covid symptoms, and no effort made to separate out people who had obviously been damaged by their...

Results Not quite sure how George Monbiot and his ilk have managed to spread the meme of Long Covid to these people... Although that easy jibe aside, surely most of these people don't have ME/CFS, or CFS/ME? Average age 60 years, 84% from an "unfavourable" economic situation, 81% with an...

Methods 80% response rate; 340 patients "Chalder Chronic Fatigue Questionnaire" 14 question, 0 to 3 Likart, range 0 to 42 Yeah right - check out commentary elsewhere on the forum if you aren't sure why I am so dismissive of the Chalder Fatigue Questionnaire.

This is a pre-print, with some issues with the English. I thought you might enjoy this typo that is probably the result of an over-zealous spell checker app. There's an issue here with confusing the symptom of chronic fatigue with chronic fatigue syndrome. Reference 13 with the global...

We have this thread dedicated to information about the impact of the new US government:Impacts of the 2024 change in US government on ME/CFS and Long Covid

We have changed the title of the thread to allow posting on the impact of the change of government on ME/CFS and Long Covid. We shall be monitoring the thread closely, to ensure posting is strictly on-topic and within our rules. In particular, please check your posting is compliant with the...

I haven't monitored things for a while - full on measuring and symptom recording takes quite a bit of effort and is rather joy-sapping. So, I can't say anything specifically about pulse pressure. With symptoms in general, no, apart from, as you say, managing activity to try not to cause PEM...

Narrow pulse pressure has been reported in at least several papers from different teams e.g. And here's another post from me about my tracking of cardiovascular measures showing the variability and association with worse symptoms:

Venous insufficiency and acrocyanosis in long COVID: dysautonomia, 2023, Iftekhar & Sivan This is a Long Covid case study where blood pressure sitting and standing was noted, but the narrow pulse pressure (as calculated from the BPs) was not noted. Low pulse pressure on standing makes me...