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I actually did laugh out loud when I saw how well they did in not extrapolating beyond their sample population. Presumably, never mind ongoing exposure to Covid-19, never mind probably inadequate protective equipment and ventilation. Just have some astragalus.

Thanks EndME, yes. Fantastic @Andy, it's getting exciting.

Step 1 - see Fig1a - the blue spike Step 2 They viewed all five of the disease as immune mediated, so, they looked for genetic enhancers acting on immune cells Step 3 Find the gene regulated by the enhancer (I'm not sure how they concluded the following as a supporting fact , but there...

You may well be right that this paper doesn't have the answer to IBD etc, although I still like the effort made to find a solution. I think they are quite careful not to call IBD an autoimmune disease. I think the point they are making in that paragraph above is that genetics can help with the...

:D Reading this paper makes me more hopeful. I don't understand a lot of this, but there's a logic to the process, things were approached from different angles to check ideas still made sense, and they clearly have great tools. It's a million miles away from the 'fill the gaps in knowledge...

Thank you Solve ME/CFS! Made my day.

So, the combination of a susceptible gene, and the non-coding variant that regulates that gene and, possibly, certain environmental conditions are needed to result in disease. Gene desert = sections without coding genes, but it's increasingly understood that they aren't just junk DNA, but...

Ha, that's probably an unsafe assumption, given the NHS is trialling the Lightning Process. But, for sure, wearables are being used in a whole range of health contexts around the world and it's widely recognised that they provide advantages in data accuracy that questionnaires do not...

We sent Österreichische Gesellschaft Für ME/CFS an email in English in September last year, and an email in German last year, to contact@mecfs.at. Both received automated responses. If anyone can help us reach decision makers in the association, or give us an alternative email address, that...

Announcement of a further Euro2.5 million in research funding: The Netherlands - €28.5 million ME/CFS research program - ZonMW funding awards announced April 2023

Over the last couple of years, I have been getting a lot less migraines, almost none, whereas they were pretty frequent before and often part of an exertion response. I was thinking about that the other day when I did have a brief and mild headache, wondering why that was. Now that you say...

I don't know what to make of this, other than, of course, it's a case study of one case from a clinic, and so suggestions of recovery could very easily not mean a lot. People often do recover from Post-Covid syndrome. The paper doesn't tell us how long the woman had been sick before starting...

That's Figure 1. Top row is before treatment; bottom row is after treatment The left panel shows DNA. They say the small blue dots are the mitochondria in the thrombocytes (platelets) which are clustered with some white blood cells (larger blue shapes). The middle red panel is The right...

From Jean Hailes for Women's Health (an Australian charity) I don't know where they got the following from, but JHWH seem like a credible organisation:

Not to diminish the hard time some people have, but the time when I had symptoms was short and not much of a problem. Just some hot flushes, I can't remember much else. Of course, with ME/CFS, there's a significant amount of time feeling rubbish, so sometimes it's hard to tell what is what...

Posts relating to Obtaining Patient Priorities in a Multiple Sclerosis Comprehensive Care Center: Beyond Patient-Reported Outcomes, 2020, Miller et al have been moved to a new thread for that study.

A is GDF-15; B is FGF-21 - levels in the acute phase disease It's just too small a sample and too confounded to tell us anything. GDF-15 Limitations So it sounds as though the 6 controls required medical treatment for more than three months.

That's what I was looking for - how many people? Turns out they looked at 13 cases at the three month mark, 7 of which were categorised as long COVID. So, 7 Long Covid; 6 controls to make this biomarker. Mean age: controls 44.5; long COVID 56 years Female percentage: controls 50%; long COVID...

From the authors' response, which is fairly long, the final paragraph: I'm not arguing with them about their actual results - it's quite likely that none of those biomarkers in blood are suitable biomarkers to identify patients with PASC. But they completely sidestep the main problem - the...

Summary: inoffensive, relatively short piece from Koroshetz, talking up NIH progress on ME/CFS (roadmap, intramural study), biological mechanisms mentioned a few times and no whiff of effort preference/BPS ideas. Last paragraph: It's almost an apology.