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Author affliations: School of Nursing, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; School of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; School of Management, Henan University of Chinese Medicine...

A post on a possible treatment for IBS has been moved to the discussion thread: Irritable Bowel Syndrome

This is an interesting paper about VWF: Performance Related Factors Are the Main Determinants of the von Willebrand Factor Response to Exhaustive Physical Exercise 2014 I'm not sure if the values can be compared, but the point is that VWF levels change a lot when people exert a lot. And the...

I think that's a fair summary. It looks as if there is a subset of PCS group who have a prothrombotic tendency, but not all of the people labelled with PCS do. I would like to know more about the PCS sample people in relation to their VWF and VWF(Ag):ADAMTS13 levels: their co-morbidities...

It's not clear to me if this study was done with the same participants. There looks to be different numbers of people in each of the experiments. There isn't that much difference in the platelets binding on the channel surfaces. Again, it seems that there is just a small proportion of PCS...

Five of the 21 PCS has elevated levels of VWF(Ag). That is something. I guess a question is, are they the people with breathlessness and chest pains? do they have ongoing tissue damage? Do the levels correlate with other symptoms? Would people with no ongoing symptoms who have had Covid-19...

It doesn't look as though the a2-antiplasmin or fibrinogen levels were very remarkable - slightly raised fibrinogen. We don't know about the BMI of the PCS group (at least so far in the paper) - obesity can increase fibrinogen levels.

1. Questions about how well the controls match A. History of Covid-19 infection So, there isn't a clear recovered control cohort - some of the controls may not have had Covid-19, only a vaccination. We aren't told how many of the controls had had COVID-19 in the last two years. We've seen that...

Ah yes, thank you, that's what I was thinking of.

Thanks Jonathan I think we have seen one study that did something like this. There was a PCA type chart, with some groups of oddly shaped particles off to the right. I'll see if I can find it. I can't recall how fresh the blood was. To play devil's advocate in a poorly thought through way...

Months on, where have we got to with this hypothesis? I think it's now clear that these "microclots" exist in processed plasma. We've seen them identified in a couple of different ways. Some of the questions that come to mind are * are these particular amyloid microclots actually in the blood...

An old paper, mentioned on another thread about the current MEA funded project to develop ME/CFS-specific PROMs.

I'd like to believe this. But I think we have to brace ourselves for an onslaught of hypothesising about prediction errors - ideas with a veneer of biology, all wrapped up in long sciencey words. Also it sounds as though there will be more "evidence" coming about "psychoeducation". And, with...

I'm sure that if people with severe ME/CFS feel unable to fill out long PROMs, there will be someone in the clinic happy to help, by filling it out for them... In which case there is plenty of point, just not for the patient. Yes, the lack of response from the MEA has been odd and concerning.

Thread for the paper here: Assessing severity of illness and outcomes of treatment in children with CFS/ME..., 2014, Haywood, Colin, Crawley

(formatting mine)

Assessing severity of illness and outcomes of treatment in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME): a systematic review of patient-reported outcome measures (PROMs) K L Haywood 1, S M Collin, E Crawley Abstract Chronic Fatigue Syndrome or Myalgic...

The moderation team has decided to not split posts off from the thread. We think the information about David's approach to his ME/CFS work is not off-topic for the thread. The small number of posts that go beyond that are difficult to separate. We have existing threads for discussing the...

I ticked the 'just put off - don't feel like having it' box. I haven't drunk much alcohol since I became ill. I don't think it makes me more ill, but I haven't really monitored that well. I will have to experiment! In a 'correlation is not causation' consideration, at least for those people...