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    Closed All eyes on PCS: analysis of the retinal microvasculature in patients with post-COVID syndrome—study protocol of 1 year prospective case–control study

    Indeed. Some parts of the study have been published and discussed here Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation.
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    True prevalence of long-COVID in a nationwide, population cohort study, 2023, Pell et al

    Add on top of that, that it's not possible to claim a group as never-infected anymore unless you do a really deep analysis including extremely extensive testing, which both are never done. One could at least analyse a subset of patients to see how valuable ones method is, but I guess that would...
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    True prevalence of long-COVID in a nationwide, population cohort study, 2023, Pell et al

    True prevalence of long-COVID in a nationwide, population cohort study Abstract Long-COVID prevalence estimates vary widely and should take account of symptoms that would have occurred anyway. Here we determine the prevalence of symptoms attributable to SARS-CoV-2 infection, taking account of...
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    Gray Matter Thickness and Subcortical Nuclear Volume in Men After SARS-CoV-2 Omicron Infection, 2023,

    Gray Matter Thickness and Subcortical Nuclear Volume in Men After SARS-CoV-2 Omicron Infection Key Points Question What are the clinical manifestations and brain microstructural changes associated with the SARS-CoV-2 Omicron variant in the acute phase after infection? Findings In this...
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    Long Covid Clinical Severity Types Based on Symptoms and Functional Disability: A Longitudinal Evaluation, 2024, Sivan et al

    Long Covid Clinical Severity Types Based on Symptoms and Functional Disability: A Longitudinal Evaluation Abstract Background: Long Covid (LC) is a multisystem clinical syndrome with Functional Disability (FD) and compromised Overall Health (OH). There is a lack of distinct clinical symptom...
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    Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis, Bjornevik et al (2022)

    A large European grant has been granted to investigate the EBV-MS hypothesis in the project „Behind-MS“, led by EBV expert Dr. Henri-Jacques Delecluse, with research happening across 6 EU-countries. Whilst the research seems to be mostly focussed on cell- and animal models they will also be...
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    Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2023, Jensen, Davis et al

    I'm guessing you're talking about the Ascherio paper. The diagnosis isn't blood based (and never is for MS afaik), but they could link the "Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration to seroconversion of EBV". I haven't had a more detailed look at what...
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    Preprint IgG Antibody Responses to Epstein-Barr Virus in ME/CFS:Their Effective Potential for Disease Diagnosis & Pathological Antigenic Mimicry, 2023, Fonseca

    Perhaps @Jonathan Edwards wants to comment on this. Does this method seem of much use? From what I’ve understood we usually understand very little about autoimmunity and from what researchers understand often the process appears to be very dynamic and complexly involved and intertwined which...
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    Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms , 2023, Rau et al

    I decided to add this work by the group of the young researcher Alexander Rau, since a news report on currently unpublished material by him, which uses similar methods as the above study, is currently making the rounds. His group also published: Neuropsychologic Profiles and Cerebral Glucose...
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    Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms , 2023, Rau et al

    Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms Abstract While neuropathological examinations in patients who died from COVID-19 revealed inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect abnormalities even in the...
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    Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study, 2023, Lundberg-Morr

    The key quote for me is the following I'd still have to deep dive into the data, but I wouldn't be surprised if the only things reduced are related to a worse acute infection even hospitalisation or respiratory/cardiological damage due to an acute infection, rather than anything related to a...
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    Long Covid in the media and social media 2023

    "Urgent call for action on long covid" - https://practicebusiness.co.uk/urgent-call-for-action-on-long-covid "As reported by BMA, the BMA and RCN are urging the government to urgently address the support for healthcare workers affected by long covid. A year ago, the Industrial Injuries...
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    Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans, 2023, Chang et al

    Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans Abstract Chikungunya virus (CHIKV) is a mosquito-borne re-emerging viral infection that can cause chronic chikungunya viral arthritic disease (CHIKVD), which is characterized by...
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    Vagus Nerve Dysfunction in the Post-COVID-19 Condition: a pilot cross sectional study, 2023, Mateu et al

    Vagus Nerve Dysfunction in the Post-COVID-19 Condition: a pilot cross sectional study Abstract Objective The post-COVID-19 condition (PCC) is a disabling syndrome affecting at least 5-10% of subjects who survive COVID-19. SARS-CoV-2 mediated vagus nerve dysfunction could explain some PCC...
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    New Study: Gargling with Salt Water May Help Prevent Covid Hospitalization

    Oh wow. Sounds a bit alarmist too me, but then again you don't want to be doing more harm than good. I suppose it'll also depend on where one is living/the quality of tapwater (apparently the main problem is Naegleria fowleri). Allegedly the FDA recommends boiling the water or using distilled...
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    New Study: Gargling with Salt Water May Help Prevent Covid Hospitalization

    I haven't read this study before but have seen similar data elsewhere, for example here: https://pubmed.ncbi.nlm.nih.gov/36007135/. Is this really the case? Carmen Scheibenbogen just advises using regular tap water with Emser Naselspülsalz (which seems a bit like a pharmaceutical marketing...
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    Opinions on payments to participants in research

    I answered “It depends”. Does payments include reimbursing transportation costs? I think it is important to make studies accessible to everybody. Other than that, I don’t think payments are overly productive. We all profit from well-conducted research and extra dollars spent there are probably...
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    Dazodalibep (VIB4920/HZN4920) in Sjögren’s Subjects with an Unacceptable Symptom Burden: Safety and Efficacy from a Phase 2, Randomized, Double-Blind

    LB0003 Dazodalibep (VIB4920/HZN4920) in Sjögren’s Subjects with an Unacceptable Symptom Burden: Safety and Efficacy from a Phase 2, Randomized, Double-Blind Study Abstract Background Sjögren’s is a systemic autoimmune disease associated with marked morbidity and poor health-related quality of...
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    Nucleocapsid protein accumulates in renal tubular epithelium of a post-COVID-19 patient, 2023, van der Wel et al

    Nucleocapsid protein accumulates in renal tubular epithelium of a post-COVID-19 patient ABSTRACT In this study, we investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins and virus particles can be detected (i) in post-mortem kidney of fatal coronavirus...
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    Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults, 2023, Gutierrez et al

    Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults Highlights We explore the association between infectious disease serologies and neuroimaging signatures Herpes simplex virus 2 was robustly associated with reduced whole-brain...
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