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The intramural study will be published in Nature Communications www.twitter.com/oslersweb/status/1722330356458693033. To me that sounds like a confirmation that they didn't find much, or at least not as much as some patients are hoping for.

Indeed (the price just for your PhD student to have an office desk is already beyond CA$20.000 per year in NL), these are two different things. Jeroen den Dunnen has funding for a PhD position (possibly as part of his ME/CFS grant by ZonMW) which he is now advertising...

Pre-print Small Fiber Neuropathy after COVID-19: A Key to Long COVID Abstract Objectives: Report a case series of new onset small fiber neuropathy (SFN) after COVID-19 treated with intravenous immunoglobulin (IVIG). SFN is a critical objective finding in long COVID and amenable to treatment...

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of mental health symptoms in patients with post-acute sequelae of SARS-CoV-2 infection (PASC) INTRODUCTION Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...

(this sentence structure is a bit confusing to me, what they are saying is that the infected COVID-19 group is younger at 56.04 years compared to the uninfected controls with 58.1 years) The massive caviat is that this study is extremely focused on the male population with only 7.8% of controls...

ASSESSMENT AND CHARACTERIZATION OF COVID-19 RELATED COGNITIVE DECLINE: RESULTS FROM A NATURAL EXPERIMENT Background: Cognitive impairment is the most common and disabling manifestation of post-acute sequelae of SARS-CoV-2. There is an urgent need for the application of more stringent methods...

Their preprint predates the work of Peluso et al by a couple of months so I suppose they can claim being the "first ones".

First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody Abstract With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is...

A classical Ruud Raijmakers review. A lot of focus on that an ME/CFS diagnosis leads to a worse outcome, instead of having ME/CFS that leads to this outcome, “strengthens the poor prognosis that ME/CFS diagnosis” have. Raijmakers probably also thinks "AIDS is a harmless syndrome, however a...

Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors Background As a debilitating condition that can impact a whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever...

Maybe someone has a clever question or 2 for Amy Proal that they want to ask. “What would you ask Dr. Amy Proal about Long COVID research?” www.twitter.com/dsethlewis/status/1720576399528886307 www.reddit.com/r/covidlonghaulers/comments/17ndh79/what_would_you_ask_dr_amy_proal_about_long_covid/

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise Editor’s summary Regulatory T cells (Tregs) support repair of injured muscle, but whether they participate in the response of healthy muscle to exercise training remains...

There are two very different arguments. On the one hand there’s the possibility of ME/CFS having different downstream effects, having different subtypes or even being a collection of different illnesses. This seems like an extremely reasonable hypothesis to me for which the very reasonable...

Oh boy there's a lot. Apart from the newer work done by some groups with a Long Covid focus and the older work by van Campen/Visser all dutch studies are essentially flawed. I'm sure @Grigor has a great historical knowledge of the abundance of crap. I'm also tagging @Lou Corsius and @dave30th ...

Am article in Nature related to these findings https://www.nature.com/articles/s41590-023-01679-8.

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used a model of viral...

Lovely! I just saw that there's a new patient organisation in Germany called StartaMEvolution. They appear to be so new that not much information is available about them at this point in time. The call themselves "SAME" which I have already once misread as "S4ME"...

A Tweet by Polybio with regards to this study “They are expanding on the findings in this study, where measurement of complement proteins in blood will be combined with analysis of potential #SARS-CoV-2 reservoir in lung tissue, and measurement of endothelial dysfunction at that site...

Merged thread Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis Abstract Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a...

Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among U.S. Veterans Background: COVID-19 has been linked to the development of many post–COVID-19 conditions (PCCs) after acute infection. Limited information is available on the effectiveness of oral...