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Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism Abstract Brain [18F]FDG-PET scans have revealed a glucose hypometabolic pattern in patients with long COVID. This hypometabolism might reflect primary astrocyte...

There has been a bit of discussion about Iwasaki's paper here and what lower cortisol could be indicative of. The sample sizes here are a lot smaller, but could still be able to add something to that discussion with lower cortisol levels only being noticeable in the mild/moderate female (edit...

Link to the published paper ******* Sex and disease severity-based analysis of steroid hormones in ME/CFS Preprint Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by decreased daily activity and persistent fatigue after physical...

A team in Germany is planning to launch a trial with the drug IMU-838 trial for Long Covid. Currently there aren’t too many details on the trial, however Maria Vehreschild of the Universitätsklinikum Frankfurt has given some details in this talk www.vimeo.com/873993707/description (from 32:30...

In my eyes it's good, I highly doubt the trial will yield any positive results (it's only an exploratory study), but unfortunately that is just the way it is. The disappointing part of the trial is that it isn’t placebo controlled, I don’t see a reason why one wouldn’t do that.

HIV to me seems like a bad example, firstly it doesn’t seem comparable to COVID-19 and is quite a “special” virus, secondly because it usually doesn’t cause symptoms related to post-viral illnesses albeit infecting cells all over the body and thirdly because it's extremely progressive if not...

Thank you! I saw the number of healthy controls but couldn't find the number of patients with Covid.

Thank you for sharing and summarising @SNT Gatchaman. Do you have details on the sample size?

As we all know viral persistence is possibly the leading hypothesis currently driving Long Covid research. There's generally two concepts on how the virus could be persisting. On the one hand via some form of viral reservoir (possibly replication competent, possibly non-cytolytic or via some...

Uses flow-mediated dilation, which is very similar to EndoPat used by other groups. A significant problem (in drawing a comparison to HC) here are the large differences in weight/BMI between the ill and healthy patients, with the BMI for LC being at 34.19, for ME/CFS at 31.49, and for HC at...

People With Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Exhibit Similarly Impaired Vascular Function Background This study aimed to compare flow-mediated dilation values between individuals with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...

Clifford J. Rosen is the Principal Investigator for the MaineHealth RECOVER site. According to healthrising "An editor for the New England Journal of Medicine, Rosen stated that he wasn’t seeing many good long-COVID papers (ouch!) and actually made a pitch for people at the conference to submit...

On Gerrit Keferstein (translated): "Through his intensive self-study with literature, further education, networking and exchange, he came across an elementary explanation of previously unknown connections between environmental influences and chronic diseases: Mitochondrial energy production...

Whilst I'm not fully convinced by 2-day CPETs, I'm also very wary of some of the claims and understanding made with respect to PEM in Long-Covid. I've talked to several Long-Covid patients who've said they had PEM, but as it turned out some of them just got shortness of breath when they...

UTILITY OF 2-DAY CARDIOPULMONARY EXERCISE TESTING PROTOCOL IN LONG-HAUL COVID (LHC) PATIENTS: PRELIMINARY DATA Purpose: Long Haul COVID (LHC) patients have prominent symptoms of fatigue and exercise limitation. Comparisons have been made between Chronic Fatigue Syndrome/Myalgic...

The patients are taken from Merel Hellemonds clinic in Rotterdam (CO-FLOW cohort). The very big caviat is that all these patients were hospitalised (48.6% respectively 61.1% required ICU treatment, average hospital stay was 17.0 resp. 15.0 days) at the beginning of the pandemic. As such patients...

Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity Background: Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling...

Translation of Tweet: There is news First post-COVID patients will be treated as of autumn 2023. Summary of website: reCOVer: BC-007 study starts. First post-COVID patients will be treated as of autumn 2023. reCOVer will be launching a Phase 2 (n=30) clinical research study into BC007 in...

I find this reasoning quite funny when it comes to Long Covid because there is an abundance of data on patients fully recovering from Covid, only to weeks later start experiencing Long Covid. Says a lot about the robustness of their model.

Thanks for sharing that, I wasn't aware of the patient feedback but had read these Tweets www.twitter.com/RobWust/status/1644202526235844609, www.twitter.com/RobWust/status/1650759252644962308, in defence of the LifeLines cohort, which might be very sensible if you aren't aware of the history of...