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Fishing for “complements” with vascular organoid models of microvascular disease In this issue of Cell Stem Cell, Kawakami et al. develop a SARS-CoV-2 infection-competent, progenitor-derived, human vascular organoid model and uncover a role for complement factor D (CFD) in mediating...

The symposium schedule with speakers and talks has been updated: https://polybio.org/polybio-fall-symposium-schedule/.

Some details on the german biobank/registry: https://classic.clinicaltrials.gov/ct2/show/NCT05778006?term=Scheibenbogen&draw=2&rank=1, https://www.bundesgesundheitsministerium.de/ministerium/ressortforschung/handlungsfelder/gesundheitsversorgung/mecfs...

They have recently reiterated how they are part of Ancestral Health. In fact two of them are even on the board (Isabel Burnett and Tess Falor) of this organisation. Organisations such as Ancestral Health are the playground for pseudoscientists like Terry Wahls ("buy my diet protocol which cures...

T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19 Over 1,000 cases of pediatric hepatitis of unknown etiology have been reported worldwide since the first case was reported in the UK. To date, the etiology of pediatric hepatitis remains unknown and controversial...

Mitochondrial proteome research: the road ahead Abstract Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell death processes. Their diverse functions are enabled by a...

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues...

Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome Abstract Epstein–Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less...

"Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC)." Apart from the Covid T2D link, I haven't seen evidence of this. But I suppose as long as Long Covid is very loosely defined one can almost...

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting...

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels Abstract Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although the systemic inflammatory response to...

Is that really the case though? If anything I feel like Iwasaki's recent publication received twice the media attention, once as preprint and later again when it was published after passing peer review. When I asked two different groups in the ME/CFS/LC field why they don't make their preprints...

Sample sizes are extremely small, but seem decently chosen with different control groups.

No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache Abstract Headache is one of the most common neurological manifestations of COVID-19, but it is unclear whether chronic headache as a symptom of...

These timeframes are rather rough suggestions than anything else. Take for example the recent Iwasaki paper published in Nature. It took one year and 1 month from submission to publication. However, they also released a preprint once they submitted the paper so that was never an issue.

For all I care they can take 2 years to peer review it. The problem is not uploading a preprint to the Arvix and that's on the authors.

His hundredth birthday can then be celebrated with the intramural study being published in the year 2041. Just in time to get the ball rolling...

Anthony Fauci on becoming the ‘devil’ and a warning for his successor In an interview with Science Anthony Fauci reviews his career and states that he believes that ME/CFS is currently the most interesting disease to study for him. Of course that has not resulted in it receiving adequate...

It was been revealed that the MuscleME study is about to start their biopsies and bicycle tests. @Grigor probably has some information on how this biobank is problematic as it involves the scandalous COFFI group, that is if I understood that corrently. Unfortunately, the other biobank...

Tonsils are major sites of persistence of SARS-CoV-2 in children ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and secretions in children without symptoms of COVID-19, with no history of recent upper airway infection. We studied 48 children...