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This study being based on the study by Bouquet et al. means that the sample sizes are very small (ME/CFS (according to CCC) n=14, HC n=11). However, a re-analysis of other studies based on similar methods should be possible.

ME/CFS is a debilitating disease with obscure aetiology. However, despite the extensive amount of research that has been performed on the transcriptomes of ME/CFS patients, all of them are solely focused on linear RNAs, and the profiling of circRNAs in ME/CFS has been completely omitted. In this...

Has anybody had a closer look at Meplazumab, https://clinicaltrials.gov/ct2/show/NCT05813587?term=Meplazumab&draw=2&rank=8, before?

"Furthermore, it is possible that some individuals in the comparison group had SARS-CoV-2 infection that was not detected by a PCR test. This risk was reduced by excluding from the analyses 53,530 participants who had only negative PCR tests recorded but who reported that they had had SARS-CoV-2...

I'm not particularly fond of the Metformin trial for people with a normal BMI. However, if it is convincing enough for people to prove that Long-Covid isn't psychological or is the last bit of evidence they needed to reach that conclusion, as suggested in this newly published paper "The...

It seems like Douglas Fraser et al. always choose the same group of patients that don't seem to represent the "classical" Long-Covid patients (predominantly female and younger patients), but rather those that seem to suffer from acute Covid more (predominantly older, a slight majority of males...