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Yes, but what does any of that mean for the public? I would argue that the only evidence we have (wastewater), shows that this is one of the largest waves not only in the US but also in Europe. But what does that matter for the public? Why should the public care about the size of the wave or...

Seems like a vain article to me. “We have lost the ability to track the actual number of infections since most people either test at home or don’t even test at all.” Makes it sound like it's the peoples fault for incorrectly testing, when in reality every government on the world gave up on...

Indeed. At least this data seems like something that could also be explained by variations occuring in the lab (taking a biopsy from a different location, some slight differences in applying the staining etc) rather than necessarily a faulty exercise response. On the other hand it might also be...

In my eyes the problem is less that "this isn't what you see in healthy or deconditioned people", but rather that an inactive control group (and also a bed-bound group of PEM patients) provides a further level of control and helps you further analyse the existing data (that doesn't mean the...

For that it is crucially important that someone actually tries to replicate already existing research, which requires the research to be methodologically strong since the replication crisis is to a very large extent a methodological crisis. It's equally important that if findings can't be...

Haven't read the study, but am I correct in assuming that they are mainly comparing ICU to non-ICU patients? If that's the case, such a study will most likely only answer questions about the severity of acute infections and outcomes associated to the severity of an acute infection rather than...

Cohort selection: n=21 healthy controls (all with previous Covid exposure) vs n=25 Long COVID patients with PEM. Controls are excellently matched according to the data presented (age, sex, BMI, no hospitalisations for acute Covid, vaccination, last known infection etc.). Perhaps males are...

The paper has now been published in Nature Communications. Muscle abnormalities worsen after post-exertional malaise in long COVID Abstract A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is...

Wasn't necessarily expecting that (he announced something in that direction on Twitter a while ago, but I can't imagine exchanging Germany for Latvia will lead to an increase in ME/CFS research budget). I wonder whether his long-term and rather sizeable grant for ME/CFS research will just carry...

I agree. To some degree BSc projects are always somewhat like that I suppose, no matter what field. Students haven’t acquired the means yet to do research, but they are supposed to gain a first experience in how research would roughly work. Often a less enjoyable experience for the students that...

Thank you for coming here, being open for feedback and engaging with us! Given that this is supposed to be a questionnaire on ME/CFS it would seem vital to me that one asks on which diagnostic criteria an ME/CFS diagnosis is based on since this is of vital importance and can completely change...

Cognitive impairement in ME/CFS, how to measure it and it's relation to PEM are largely unexplored so the title seems good. However, I can't read the paper since it isn't open access...

It also matches what I've heard amongst patients in the ME/CFS and neurocognitive subset of LC patients and it is the exact same thing that happened to me. I also always fully recovered from the acute Covid phase and only later developed symptoms of LC/ME/CFS. Retrospectively one might say that...

Given some of the recent genetic findings on Raynaud’s I was wondering if that is somehow partially assessed in one of the DecodeME questionnaires (I fully understand that there’s also a rather smaller upper limit to what can be assessed)?

There seems to a lot of stuff going on this front at least if I'm to trust newsreport headlines. In particular continuous lactate measurement devices (continuous lactate monitors) are starting to become a popular topic especially in professional sports such as cycling...

Considering the lack of any meaningful scientific rigor displayed in different subfields of psychology and psychiatry by some influential researchers it isn’t surprising that exactly these fields currently have a massive replication crisis and a long history of “wrong and harmful statements that...

This group wrote a series of papers on this topic. Another one was discussed here.

cerebral blood flow [27,28,29] - I've always thought these findings are very interesting but they are findings from one group of doctors that only do this experiment in their own practice and this experiment is sort of the selling point of their practice. Unfortunately, as of today the findings...

I don’t know how this could be a fruitful direction of research, especially when something has 0 influence on the quality of life since it can easily be avoided. Furthermore people with LC or ME often have some form of brain dysfunction and/or gut problems and often even headaches so it wouldn’t...

I also think studying blood regulation seems like a very useful approach and I think there should also be some novel ideas to try to understand whether autoimmunity plays a part in ME/CFS, but I don't think that every research that somehow looks at autoimmunity should be focused solely on...