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Persistence of an infectious form of SARS-CoV-2 post protease inhibitor treatment of permissive cells in vitro Reports have described SARS-CoV-2 rebound in COVID-19 patients treated with nirmatrelvir, a 3CL protease inhibitor. The cause remains a mystery, although drug resistance, re-infection...

This is peak shithousery commonly witnessed amongst such groups financially profiting from the products they advertise: I am part of said group -> Everything they do is perfect, it's "science", no questions allowed. I am not part of said group anymore -> Everything they do is harmful, follow me...

I struggle to see how such a model bares any relevance to reality. The modelling of the noise, which is the essence of the model, is completely arbitrary. They want to see some basic dynamics, so they just use an SDE with constant diffusion. My guess is that the authors were very motivated by...

No, you just have to fill out your name in the google doc form, several researchers and organisations as well as patients that aren't US citizens/taxpayers have signed. It would also be possible for S4ME to sign the letter as organisation (I guess that would require the members/board to...

Same team that published opposing results in https://www.sciencedirect.com/science/article/pii/S0889159123000065?via%3Dihub.

Cerebrospinal fluid findings in patients with neurological manifestations in post-COVID-19 syndrome Background Information on cerebrospinal fluid (CSF) findings in patients with neurological manifestations in post-COVID-19 syndrome is scarce. Methods Retrospective evaluation of 84 CSF samples...

Indeed. I was also disappointed by the lack of signatures of patients. Certainly signatures of researchers, clinicans and organisations are far more important but not even getting anywhere close to 1000 patient/ally signatures is somewhat disappointing. Wouldn't be surpised if this letter...

I don’t have any expertise to judge such work, but I feel like a lot goes missing when you’re studying a persistent infection in-vitro without evidence of it existing in-vivo. After all the persistency is supposed to be taken care of by complex immune systemic mechanisms which could probably be...

Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model Highlights Persistent SARS-CoV-2 infection model of human cardiac tissue was established Hypoxic stress to the persistent infection model led to cardiac dysfunction ACE2 and...

Paper has now been published in JCI Insight - https://insight.jci.org/articles/view/166540#F4.

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Abstract To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and...

Just like the rest of the paper unfortunately. 15 authors for a mundane review full of errors passes peer review, are they all just bots?

Enough internet for today...

Thanks for sharing @Dolphin and lovely that medicalnewsbulletin covered this. The article opens with Is that really the case? Has anybody looked at muscle cells in particular in relation to post exertional malaise? From what I can tell Rob Wüsts exploratory, not yet published data, would...

Van Vugt told me in a conversation a couple of months ago that they applied for a new grant in a new government funding round so that they could continue their IDO2 work in LC. It is my interpretation that they meant these grants, because I'm not aware of any other funding (but it still means...

Thank you. Yes, that's what I meant.

That is something I don't know (I believe to know Wüst/van Vugt did), but I would be surprised if one of them hadn't, especially since their CBT study was "successful".

Most of the patients were hospitalised (17 out of 21) are also more than 10 years older than the control group on average and have a much higher BMI. I cannot see what the mean Long-Covid duration is, but they recruited patients 4–16 weeks after a COVID-19 infection, which seems far too early to...

Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver Abstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long...

Yes, on the other hand for the above paper, since it's a large majority of elderly males that have only been sick for a shorter time period (<6 months), I expect that the majority of them will probably have self-resolved fatigue as typical for many viral infections. Unless your goal is to...