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Great find, could be valuable if someone shared this with the team of Rob Wüst, perhaps they haven't seen it either.

FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis Highlights CD320 expression is suppressed in MS and EAE astrocytes S1P1 inhibition upregulates CD320 expression in astrocytes Fingolimod and sphingosine directly bind to...

Dementia and mortality in older adults: A twin study Highlights We studied dementia and mortality in twin pairs discordant for dementia. People without dementia outlived people with dementia. Identical twins with dementia and their co-twin controls had similar survival time. Findings suggest...

In vitro B cell experiments explore the role of CD24, CD38 and energy metabolism in ME/CFS Disturbances of energy metabolism contribute to clinical manifestations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Previously we found that B cells from ME/CFS patients have...

It seems to me that it would be fairly easy and useful to do some statistically significant sampling of health records within the CDC study or a similar one (sampling a subset of the patients in the survey to have doctors appointments would also be great, but probably too much effort). The...

Cohort characteristics: Matching isn't perfect with LC patients having quite a few pre-existing conditions (as they mention in the limitations section these pre-existing health conditions make it harder to draw conclusions): They used NIRS, previously discussed here They also mention that...

Now published - final abstract here Preprint Mechanisms underlying exercise intolerance in Long COVID: an accumulation of multi-system dysfunction The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus ('Long COVID') is not fully...

Now published as Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Demystifying Long COVID International Conference 2023 | Day 3 www.youtube.com/watch?v=AP3qHM3Acz4 Program "A Patient Perspective" Chantal Britt Pauline Oustric "A Perspective from a Family Doctor" - Gemma Torrell "A Two-Sided Coin: A Clinician and a Patient Perspective" - Annemarie...

A recording of the talk, as well as of every other talk can also be found on YouTube www.youtube.com/watch?v=gEsjR2y6fzs. When such "phenomenal" and very interesting preliminary results, which do significantly differ from previous results, are presented by a new team from a "smaller" lab I find...

Not necessarily. It's also explainable by ME/CFS patients having a lower live expectancy than healthy people. I believe there is sufficient evidence and reasoning to make such a claim, albeit ME/CFS not being a directly deadly disease (lower income, less accessibility to health care and...

Overview of the study Using data from the 2023 Canadian COVID-19 Antibody and Health Survey – Follow-up questionnaire (CCAHS- FQ),1 this article provides updated estimates on COVID-19 infections and reinfections among Canadian adults, and describes the nature of symptoms experienced as a result...

This link should work (only the first part of the above link appears to be broken): https://link.springer.com/article/10.1007/s15006-023-2894-z.

Doing something about that is clearly not an option. Instead, perhaps the general public and especially these economists overfocused on facts and evidence should have to do CBT so that they can ignore these high economic costs and don’t become hypersensitive to them? Is CBT for economists a...

Wow, roughly 4,3 million people in the US alone and this does not include undiagnosed patients as the survey is based on a doctors diagnosis! If true, that would be an extremely high prevalence, between 3-4 times that of MS or roughly double of MS and HIV combined. I wonder how much of an...

Ziyad Al-Aly is a strong and outspoken advocate for LC with many well-cited papers on LC that have been discussed on this forum. I agree with your interpretation. I think that probably has a lot do with the patients he is looking at and the type of research he is doing. His research is...

Moved post The conference "Demystifying Long COVID International Conference 2023" is talking place from 7.12.2023-12.12.2023 in Madrid, Spain. Attendance for patients with Long-COVID is free of charge (both online and in-person). Patients with Long-COVID can register free of charge by writing...

I would even say it's better to try these tests on people with severe and very severe ME as well. Usually this patient group is excluded from any research, however “two short web-based cognitive tasks, Simple Reaction Time (SRT) and Number Vigilance Test (NVT)” would be something that could...

It could potentially require a different analysis and might not be true since "A predicting B" is a different statement than "B predicting A". I doubt it's worth reading through the study to be able to tell whether the argument they made is symmetric, since the most probable outcome is anyways...

Preprint Now published, see post 5 Long COVID is associated with severe cognitive slowing Background COVID-19 survivors may suffer from a wide range of chronic cognitive symptoms for months or years as part of post-COVID-19 conditions (PCC). To date, there is no definitive objective cognitive...