Search results

The main reason is that the HPA axis hypofunction is a consequence, not a cause, of immunological alteration. Also, using hydrocortisone could aggravate immunodeficiency and EBV reactivation.

Well said. My muscle strength switches on and off for no obvious reason. I try to lift small amounts of weights on good days to maintain some strength, small amounts are better than doing nothing, but I have days/weeks/months that I can't do 4 reps so it's full stop. Same with muscle...

Abstract Post-infectious conditions, where clinical symptoms fail to resolve even after pathogen clearance, present major health burdens. However, the mechanisms involved remain poorly understood. In Chagas disease (CD), caused by the parasite Trypanosoma cruzi, antiparasitic agents can clear...

Summary Menopause is the cessation of ovarian function, with loss of reproductive hormone production and irreversible loss of fertility. It is a natural part of reproductive aging. The physiology of the menopause is complex and incompletely understood. Globally, menopause occurs around the age...

From the article: "The red flags that Twinam had an unrecognized chronic illness began after her suspected case of mono in high school. She says she feels she never fully recovered. One big tell: In college, after exercising, Twinam would not experience an endorphin rush.. Instead, she told her...

Abstract Multiple sclerosis (MS) is an immune inflammatory disease that causes demyelination of the white matter of the central nervous system. It is generally accepted that the etiology of MS is multifactorial and believed to be a complex interplay between genetic susceptibility, environmental...

I had refreshing sleep w/o cognitive impairment the first 11 years of M.E. from a sudden viral onset. The type of virus I got was insignificant , the virus attacked my thyroid. An M.E specialist with 25 yrs experience dx me with 'atypical M.E" in 1992. Over the years I eventually developed...

I took Forskolin years ago with no effect.

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood cells (RBCs). RBC deformability is a key...

Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...

Abstract Purpose Eighty percent of patients infected by SARS-CoV-2 report persistence of one symptom beyond the 4-week convalescent period. Those with orthostatic tachycardia and orthostatic symptoms mimicking postural tachycardia syndrome, they are defined as Long-COVID POTS [LCP]. This...

Dr. Leana Wen who was a regular commentator on CNN compared wearing masks to every day risks, such as falls, car accidents or drowning started easing her precautions on wearing masks last year when she decided not to put her children's childhood 'on hold' in an effort to eliminate all risks...

My stamina has stayed around the same in the last 23 years of M.E. A viral infection and added menopause has lowered it a bit, which is a normal response for normal people too. I definitely can not increase my activity levels or PEM sets in.

Background: There is mounting evidence suggesting that autoimmune encephalitis (AE) can be observed as a neurological complication in patients with COVID-19. This review aimed to summarize the clinical manifestations, types, and outcomes of COVID-19-associated AE. Methods: A systematic search...

Abstract Purpose Various systems are available for cardiopulmonary exercise testing (CPET), but their accuracy remains largely unexplored. We evaluate the accuracy of 15 popular CPET systems to assess respiratory variables, substrate use, and energy expenditure during simulated exercise...

Abstract Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients...

https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-09-12/04-COVID-Saydah-508.pdf

Traditional vaccines work by teaching the immune system to recognize a virus or bacteria that needs to be attacked. Now, researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) say they have developed a new vaccine that does just the opposite by removing the...

Health Canada approves updated Moderna vaccine for COVID-19 OTTAWA - Health Canada has authorized the use of an updated Moderna vaccine for COVID-19 for all Canadians over the age of six months...

Abstract Nirmatrelvir is a specific antiviral targeting the main protease (Mpro) of SARS-CoV-2, and has been approved to treat COVID-191,2. As an RNA virus characterized by high mutation rates, whether SARS-CoV-2 will develop resistance to nirmatrelvir is a concern. Our previous studies have...