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Beyond that, they don't say why they only looked at the PCC. I wonder if they looked at other parts of the brain. The methods section says they looked at all of these molecules: Alanine, Aspartate, Cr, PCr, γ-Aminobutyric acid (GABA), Glucose, Gln, Glu, GPC, PCh, Glutathione, Ins, Lactate...

Cytokines Levels of cytokines that were different between two disease levels, Extremely Severe A and Extremely Severe D (the difference being largely in the capability to listen to speech, read and write on a keyboard): The comparison is only between the two disease levels, with no reference to...

Severity levels Figure 3 gives an interesting definition of severity levels, with additional sub levels added for extremely severe. I like the definitions of the milder levels. I'm not sure about the difference between Very Severe and Extremely Severe A, which seems to have a lot to do with...

Improving Wikipedia's references to ME/CFS We have this thread in the Advocacy Projects section about efforts to improve Wikipedia's information relevant to ME/CFS.

Yes, and well-informed rehab people, including Physios for ME, are likely to be particularly successful at getting their colleagues up to date. For sure, just because someone is on our side, it doesn't mean we have to agree with everything they say or do. Those who missed this blog might like...

I understood that wrong, but I think it's worse. They don't know if the cortical thickness in the two regions noted are actually any less thick than those of people who don't have post-Covid condition. What they are saying is that there is a significant correlation between thickness of each...

There's a paywall. I'm interested to know something about the characteristics of the participants - were they hospitalised during the acute Covid-19 infection? How old are they? Interesting that they found cognitive impairment. Frascati criteria? Seems to be an HIV thing: HIV-associated...

Just a word on the effectiveness rating which was headlined in the abstract: Those percentages sound useful. However, effectiveness was measured by whether the pain rating at Time 1 (which was when the chilli extract was applied to the lip and when the acupuncture treatment was started) was...

The pain treatment was a chilli extract applied to the lip for 15 minutes. The sham acupuncture was at a site deemed inactive, and the skin was not broken. It looks as though only with the real acupuncture treatment was the needle 'lifted' and 'thrusted' and 'twirled'. Of the 64 people who...

Ah, sorry. Oh well, I guess we have time to prepare :)

I think this is on in an hour and a half, it will be an interesting one It would be good to have plenty of the people who have looked closely at the NIH study and Walitt's background on the call.

Myography method:

2 to 4 weeks between each trial of exercise

Swedish study, Karolinksa, does anyone recognise the names? I think it could be an ok study in broad concept - if people with PEM want to maintain fitness and muscle tone, what is the least damaging way to go about it? But, this is why the definition of PEM matters. If you take my experience...

:rofl: oh my goodness. That is telling them. Thanks for the laugh @SNT Gatchaman, and thanks to David Putrino for the passion and for caring. Nice to see the number of likes on the tweets. We aren't alone in thinking these thoughts.

Even the 'non-epileptic' isn't needed. As far as I can see, in some cases at least, there could be epileptic brain activity that isn't being identified by the technology used. If the abnormal electrical activity is not on the surface of the brain, it is not necessarily being picked up. So...

The approach seems to help make journals unimportant in making information accessible. Which is actually probably fine, because although in theory journals are working to ensure only credible quality research is published, in practice outcomes are a long way from that. It's reader beware...

It's an interesting finding for sure, but there's that speculative leap from ceramide plasma levels to cellular levels. In Type 2 diabetes, the reports were that plasma levels were high, and that levels are also high in mitochondria. But in this study all we know is that plasma levels are...

Well-known, famous people with ME/CFS (public thread) A K-pop star has announced that she has CFS

It does matter to Hannah, because if she knows the fridge repairers have the 'green men in the fridge' idea, she can choose a different fridge repairer who she believes is likely to think more rationally about a range of things. It also matters because if people believe in green men in the...