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Thanks for posting @Amw66 “Position-dependent function of human sequence-specific transcription factors” by Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz and Christopher Benner, 17 July 2024, Nature. DOI...

There was a lot here that I found worth thinking about. I'm not the target audience - I think therapists would find the paper worth reading, and I'd like them to read it. I wonder if the academic language would be off-putting, as it was to me. Perhaps the author could consider writing a...

Second part of the paper - what 'psy practitioners' can do to be better and actually help. My comments here aren't necessarily a summary of what is said but my response and ideas of actions that might flow from the points made. be aware of oppressive power systems; assist people with personal...

I struggle with the language that I guess is part of this academic field, but there are interesting ideas e.g. The 'you are making a big deal over nothing and seeking attention, dear, just get on with things as a man would'. I do wonder if this plays into the lower rates of diagnosis of these...

From that thread:

There is some discussion of it in this post and some that follow in that thread: FREE Long Covid and ME/CFS Holistic Healing VIRTUAL SUMMIT July 10-16, 2023

From the discussion: Ref #53 is Plasma Markers of Neurologic Injury and Inflammation in People With ... Neurologic Post acute Sequelae of SARS-CoV-2 Infection, 2022, Peluso et al That study only found elevated GFAP early in the disease of those with Long Covid, and not later. I get the...

I note the affiliation of the senior author: Matthew Campbell View ORCID ID profile Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland...

I've just looked at reference 65 - thread here Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment, 2024, Greene et al Although the cohorts were small (e.g. 11), the results from the MRI with contrast did look pretty...

Coming back to this, given that Nath recently said that he was confident that there is no blood brain barrier dysfunction in Long Covid. The findings on blood-brain barrier dysfunction based on the MRI scanning with contrast still look pretty good.

The abstract of the preprint is in 2023 is in the first post and the published abstract is at this post. It looks as though the paper received quite a bit more polishing. Also, there's substantially more on gene expression.

Montpellier, France It wasn't that difficult to believe the disease could be chronic. But at least this team understands that there is no treatment. (Perhaps 'basic' is a translation error? perhaps meaning 'disease-modifying'?) I'm aware that Jonathan doesn't think much of the idea of NETs...

If childhood abuse did cause Long Covid, it would be great if governments suddenly decided that there was an economic reason to stop childhood abuse and set about reducing it. But I suspect the response to any such association would not be to fix society. Perhaps some of the people who do these...

From the abstract, I think the argument is a bit more nuanced than 'you can only study things that are acceptable to the target population'. The wording is 'properly take account of'. There is also the 'even if it requires other experts to determine how those reasons are best to be respected in...

It doesn't sound terrible, but the outcome looks to be a subjective one: So, we have the common problem of a subjective outcome in an unblinded study, and confounded by some likely disease-unrelated improvements in wellbeing resulting from weight loss in those participants fortunate enough to...

Results of a brain scanning study from a Canadian team is out: A Multimodal Magnetic Resonance Imaging Study on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Feasibility and Clinical Correlation, 2024, Kaur Mentions a patient registry.

Yes, that paper: was the one I was looking at too. And they did find a relationship between the cerebral NAA and cognitive abilities, as the title suggests. With respect to actual measured IQ, the abstract goes on to say: I haven't looked further into the paper, but it sounds as though they...

So, magnetic resonance spectroscopy only in three regions of interest: anterior cingulate gyrus (ACC), left dorsolateral prefrontal cortex (L-DLPFC) and the brain stem (BS). Patient selection looks to have been fine - i.e. from a registry, diagnosis confirmed by physician interview, PEM...

Transcript of the spoken message on the tweet: Much respect for the effort the people involved in the Chronic Collaboration have put in over the years. However, I do hope that they will think carefully about their documentary. Just because it is a doctor who has said something, that doesn't...

A thread relevant to Gladwell: Open letter to Action for ME with concerns about their promotion of a problematic Care and Support Plan Template regarding his authorship of AfME documents and involvement in UK ME/CFS charities.