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A post about the death of a young doctor with Long Covid has been used to create an In Memory thread here Abhijeet Tavare

A number of posts about the recent White House Announcement of a national plan to address Long Covid have been moved here: USA: The White House: Memorandum on Addressing the Long-Term Effects of COVID-⁠19

Abnormal quantitative pupillary light responses following COVID-19, 2022, Bitirgen et al new study out, finding issues with pupil contraction, although, at first glance, different to what Bansal reported.

Prof. Karl Lauterbach, Federal Minister of Health for Germany on Long Covid Long Covid in the media and social media 2022

That's pretty major news. I've woken up this morning to hear the Biden announcement about Long Covid mentioned in New Zealand's Radio National hourly news bulletin.

That's an interesting paper strategist. I've made a thread for it here: Time course of exercise induced alterations in daily activity in CFS, 2005, Black and McCully For me, that's more possible. For the first time, I stood by the side of the road for 15 minutes waiting to be picked up and...

This brief note was mentioned by @strategist. It's interesting in terms of exercise physiology evidence, but the sample size is very small. I think it's most interesting in terms of history. In 2005, Black and McCully realised that their initial analysis had led them to a faulty conclusion...

2005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280928/ Abstract In a previous study we demonstrated that while people with CFS had lower daily activity levels than control subjects, they were able to increase daily activity via a daily walking program. We reanalyzed our data to determine...

That's interesting Mij. Lots of us get migraines, has anyone tried this drug?

I'm not sure what I said, but 1. 2 day CPET's don't guarantee that the person feels that they have PEM on the second test. I had PEM (feeling terrible and exhausted, body feeling crushed, glands up, the night after the first test, but felt ok (PEM-free) for the second test (but still showed the...

Although I think there are probably some important metabolites identified in this study, it's not correct to suggest that the 32 variables add up to a method of diagnosing severe ME/CFS. At the moment, the 32 variables are required to separate the 15 severe ME/CFS from the 15 healthy controls...

It's a reasonable concern. We have talked about ways that the CPET finding might be actively or unconsciously manipulated on the forum. From memory, the concern was about VO2 max and more about researchers stopping people with ME/CFS too early out of an abundance of caution, or perhaps wanting...

Indeed. It appears that in 2019, Nicola Bray was at a conference in San Diego making presentations with these titles on the basis of this research. 273 – A Multidisciplinary Integrated Treatment Approach is Superior to Standard Care for Functional Gastrointestinal Disorders (FGIDS): A...

Here's Snow Leopard explaining the issue of lowered work rate at the ventilatory threshold from another thread:

@Snow Leopard can give us the details of the physiology, but I just want to say that when I did my second CPET test, I did not feel worse at all, I felt better. (I was part of a study where there was a two day delay between tests - I had overt PEM on the night after the first test but was ok...

I've just realised I did misunderstand a bit - the 95% confidence interval for change for the controls was 0.6 worse to 4.0 better. (All the numbers except for the 0.6 are negative, indicating improvements.) There's still issues with the chart though.

no controls, natural recovery substantial dropouts, with only 8 of the 27 participants recruited providing qualitative feedback Presumably the Singstrong people will be sending notes to the Welsh National Opera people on how to ensure a positive result for an intervention

I think there might be a problem with the presentation of the data in the chart too. It's hard to tell with no tick marks on the axis, but this is what we are told: So, the text says that the control's 95% confidence interval for change in symptoms is from 0.6 [worsening] to 4.0...

I honestly approached this study with an open mind - I thought, maybe stress can impact on gastro-intestinal symptoms. But this is a really bad paper, it is unusable as far as evidence goes. I'm going to record the researchers names here. Nicola A. Bray, Natasha A. Koloski, Michael P. Jones...

A mixed linear model for data analysis - always a bit of a black box, a chance for data fiddling. Just to repeat that, of the eighty patients that they managed to convince to try one session, 35% dropped out before the end of the treatment. No mention of that in the abstract. Do we think that...