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  1. Jonathan Edwards

    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    Very likely. Fodor attracted contradictions. I think he said that what ever intentionality was it must be something else.
  2. Jonathan Edwards

    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    There's a book called that by the philosopher Jerry Fodor. All about 'mentalese'.
  3. Jonathan Edwards

    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    Is this blog a summary of an article somewhere else or is that just a mistake in the description? Maybe I should write a reply? Or maybe leave it alone?
  4. Jonathan Edwards

    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    Several of the leaders of the psychosomatic wing are now jumping off the ME train with the reason that they’re bullied by the patients. This claim was examined in England, and no grounds for such accusations were found. The truth is rather that many of them realise they’re on a sinking ship and...
  5. Jonathan Edwards

    B-Lymphocyte Depletion in Patients With ME/cfs: A Randomized, Double-Blind, Placebo-Controlled Trial (2019) Fluge et al

    There is something odd about access to this. I cannot get it through my college account. I would have to use something called Athens that I do not have a registration for.
  6. Jonathan Edwards

    Hidden disability: The young film-maker shining a light on hidden illness (EDS)

    Why does the BBC place this piece under entertainment and arts? Is it pure voyeurism?
  7. Jonathan Edwards

    Hidden disability: The young film-maker shining a light on hidden illness (EDS)

    Yes, there is a problem here. The textbook prevalence of EDS is 1/5000. The recent UK Biobank work seems to have turned up a self-reported prevalence of 1/4000. So that is well within expected uncertainty. But the article is suggesting 1/24. Something is adrift here. I also do not quite...
  8. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Sorry @JenB but you are illustrating just how little you understand about this. Is a dog clearly distinct from a cat? Are their features non-overlapping? Of course not. They both have four legs, but the shape of the leg is always rather district. The both have two eyes but the retinal structure...
  9. Jonathan Edwards

    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    I think the department of medicine at UCLH formed a fairly good idea of why these treatments are so controversial today. They seemed to readily accept the answer that the treatments have not been shown to work and probably do not work very well if at all. The authors here are perspicacious...
  10. Jonathan Edwards

    A general thread on the PACE trial!

    Just to note that I presented my thoughts about trials of therapist-delivered treatments for ME and MUS to the department of Medicine at UCLH today. The session seemed to go well and comments were positive. Nobody disagreed with my analysis. I do not expect any immediate spin off from this but...
  11. Jonathan Edwards

    Rituximab and placebo response

    The discussion so far seems to me of interest. I may not have worded the opening post perfectly but I was sort of being devil's advocate. Clearly we are talking about the wider phenomenon of systematic expectation bias plus all the other factors that make people seem to improve in trials like...
  12. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Dear @JenB, I think this is the problem. You are not a skilled neurologist or a neuroscientist so you are unaware of the many inconsistencies in the explanation for your story that you and Jeff are proposing. Biomedical science is not just talk using biomedical terms, it is about explanations...
  13. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Just a few more comments. My take on the assessment of outcome is that it is very surgical and likely to be over-optimistic about some things. I note that several patients had further surgery - probably as a knock on effect of immobilisation affecting levels further down. He finishes off with...
  14. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Interesting video @Sly Saint. Henderson comes across as a typical surgeon of a reasonably cautious type. His account of hEDS and the spine problems is very much parroted from the books and old school style. There is a conspicuous absence of a 'fresh critical eye' in his presentation but that...
  15. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    I can't work out what your post is about @Tilly. You mention neurology and lungs but you quote me mentioning mast cells in arthritis. Mast cells have nothing of interest to do with arthritis. There is an upsurge of blather about all sorts of things these days, and an acceptance of blather too...
  16. Jonathan Edwards

    EDS, hypermobility, and the link, if any, to ME/CFS

    Apparently the self reported rate of EDS in the recent UKBiobank study of 350,000 people was 1/4000 - not too far off 1/5000.
  17. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    A number of people have claimed to have improved with anti-virals, including anti-retrovirals.
  18. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    I think the important thing to remember here is that a skilled neurologist does not simply tick boxes for speech or vision problems. When I was a student I had a flatmate whose holiday job was checking potato fields for plants the wrong variety. After a week of intensive training he could tell...
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