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I guess the rest were so ill, they just slept through the whole thing.

Abbass' 2009 systematic review and metaanalysis reveals basically no improvements on objective findings in the few studies that bothered to measure them. The one outcome that was occasionally measured was healthcare utilisation, but it is important to note that less healthcare utilisation can...

Asserting that labels matter without strong evidence just shows us what inherent biases they have...

The answer is that just lactate is insufficient to trigger sensations and is also insufficient to provide a perception of effort. You might remember this study from Light/Pollack that has been discussed here and elsewhere (Phoenix Rising, Health Rising)...

This is really upsetting and disappointing. There aren't many people with ME or CFS who need NDIS services, but those who do need them, need such services badly (because they're mostly bed-bound!)

Best I could do on short notice: Exercise promoted Viley to cause Injury and Lethargy trial.

More evidence the PACE trial was not a controlled trial.

It's quite easy, just do some kind of rapid high power activity. This easily exceeds the power available through aerobic metabolism. I'd also like to point out once again, that the anaerobic threshold is well below maximum ventilation, in fact my VO2 consumption at the ventilatory threshold was...

The bump due to imputation is suspicious, but there were no differences in the ALSPAC data and the overall proportion was small, so any claims that obesity somehow is a precipitating or perpetuating factor for CFS in children is obviously false.

(note the following is not directly related to the Palmerston study, which is not directly studying what I am proposing) I thought I made it clear that the ventilatory threshold is not due to people being "out of breath" at all, it is achieved much sooner than that. The ventilatory threshold...

I had an experience like that too, developing symptoms pretty much straight after my last exam and it was summertime - but it ended up being an actual infection and lasted quite some time - 3 weeks then the virus seemed to come back for another round. (I get ill just as often in summer as...

I agree, but I don't believe limiting heartrate on its own is a magic strategy to prevent PEM. Quite frankly, it just sounds like a recipe for deconditioning, since patients will learn to specifically avoid even brief moments of intense activity.

I suggest it has central significance as the ventilatory threshold correlates with the increase in perception of effort across almost all patient groups and healthy controls where the test is limited by muscle fatigue, rather than ventilation difficulties (for example, COPD is limited by...

I'm not sure this "90%" is generalisable at all. Such claims were made based on studies in the 90s when medical practitioners had less knowledge or confidence to make a CFS diagnosis. I think diagnosis rates vary greatly by region and access to (appropriate) medical care. The recent CDC study...

Not specifically. But I personally have not observed cognitive exertion leading to PEM issues in the rest of my body. (example, exams at uni). Whereas PEM induced through exercise does induce cognitive issues. (and increased cognitive exertion does lead to cognitive issues the next day)

All comes back to the question, what evidence is there that many of these GET patients are actually increasing their activity levels? A change in questionnaire answering behaviour is not the same as an increase in activity or activity intensity.

As they say, a bad workman always blames his tools. If the researchers are inappropriately generalising effects based on p values, the problem is the researcher, not the statistical tool.

No, I'm just saying that there is a long list of infections associated and overly focusing on the specifics of one of them might be a waste of time.

If it is positive, it will be a shit storm as the trial was unblinded...

Lots of people claim a non-specific infectious trigger. I don't see the big deal. The fact they didn't name it is because the infection wasn't characterised. This is a clear bias.