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  1. Andy

    Hypothesis Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and ... 2023 Wirth and Löhn

    Full title: Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...
  2. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    Transcript and audio only version of the webinar now available here, https://www.decodeme.org.uk/webinar-recording-and-transcript-second-questionnaire/ And, separately, the final email newsletter for the year. "As we approach the end of the year, we wanted to thank you for everything we have...
  3. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    Also now available on YouTube I anticipate, but don't know for certain, that the transcript will be available next week.
  4. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    Thank you Trish, I'll pass your comment along so that the many people behind the scenes know that their hard work is appreciated.
  5. Andy

    GDF15 linked to maternal risk of nausea and vomiting during pregnancy 2023 Fejzo et al (hyperemesis gravidarum - morning sickness in pregnancy)

    Thought this also seemed interesting, GDF15 promotes weight loss by enhancing energy expenditure in muscle, 2023, Wang et al Abstract Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people...
  6. Andy

    Systems thinking, subjective findings and diagnostic “pigeonholing” in ME/CFS: A mainly qualitative public health study... 2023 Habermann-Horstmeier

    Full title: Systems thinking, subjective findings and diagnostic “pigeonholing” in ME/CFS: A mainly qualitative public health study from a patient perspective Abstract Background ME/CFS (Myalgic encephalomyelitis/chronic fatigue syndrome) is an illness that is predominantly viewed as a...
  7. Andy

    United Kingdom: Action for ME (AfME) news

    New Genetics Research Grant Secured launching LOCOME "PrecisionLife Project Awarded Innovate UK Grant to Improve Diagnosis and Treatment of ME/CFS and Long Covid Innovative precision medicine project to diagnose ME/CFS more accurately and long Covid and find the most appropriate treatment...
  8. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    The recording of the webinar can be watched on Facebook here, https://www.facebook.com/decodeMEstudy/videos/795507245717308 Transcript will follow in due course, as will it being available on YouTube.
  9. Andy

    Pediatric and Adult Patients with ME/CFS following COVID-19: A Structured Approach to Diagnosis Using the MBSQ, 2023, Peo et al.

    Lenny Jason is now added to the list of authors, Laura-Carlotta Peo, Katharina Wiehler, Johannes Paulick, Katrin Gerrer, Ariane Leone, Anja Viereck, Matthias Haegele, Silvia Stojanov, Cordula Warlitz, Silvia Augustin, Martin Alberer, Daniel B. R. Hattesohl, Laura Froehlich, Carmen...
  10. Andy

    Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study, 2023, Xie, Al-Aly et al.

    ‘Long flu’: study finds flu patients at higher risk of longer-term illness "People who have been hospitalised with flu are at an increased risk of longer-term health problems, similar to those with long Covid, data suggests. While the symptoms associated with such “long flu” appear to be more...
  11. Andy

    GDF15 linked to maternal risk of nausea and vomiting during pregnancy 2023 Fejzo et al (hyperemesis gravidarum - morning sickness in pregnancy)

    Of possible interest is this study, Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome, 2019, Melvin, Lacerda, Nacul et al
  12. Andy

    GDF15 linked to maternal risk of nausea and vomiting during pregnancy 2023 Fejzo et al (hyperemesis gravidarum - morning sickness in pregnancy)

    Extreme morning sickness? Scientists finally pinpoint a possible cause "Researchers have pinpointed a hormone released by growing fetuses that might cause a debilitating form of morning sickness. Women who are more sensitive to the hormone, which increases during early pregnancy, might be at...
  13. Andy

    GDF15 linked to maternal risk of nausea and vomiting during pregnancy 2023 Fejzo et al (hyperemesis gravidarum - morning sickness in pregnancy)

    Merged thread Abstract GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy (NVP) including its most severe form, Hyperemesis Gravidarum (HG), but a full mechanistic understanding is lacking [1-4]. Here we report that fetal production of GDF15...
  14. Andy

    Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons 2023 Smith et al

    Neurons responsible for poor sleep and stress found in mice "Researchers have now identified a group of neurons in the brains of mice that are involved in regulating blips of wakefulness, called microarousals. The finding1 could help to explain how stress disrupts sleep, says Ketema Paul, a...
  15. Andy

    Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons 2023 Smith et al

    Highlights POA glutamatergic neurons become activated during microarousals in NREM sleep Stress activates POA glutamatergic neurons, leading to fragmented sleep Inhibiting POA glutamatergic neurons attenuates stress-induced sleep fragmentation Presynaptic inputs in the lateral hypothalamus...
  16. Andy

    Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition 2023 Gerrick et al

    This group of bizarre gut microbes is unexpectedly complex "Alongside the bacteria, fungi and other organisms living in our guts are single-celled, nucleus-bearing microorganisms called protists. A study in mice — whose protists are related to some found in humans — now shows how these...
  17. Andy

    Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition 2023 Gerrick et al

    Highlights Metabolic diversity in protists drives convergent Th1/Th17, but divergent Th2, immunity Protists’ preference for fiber or mucus shapes trans-kingdom competition with bacteria During fiber starvation, bacteria outcompete Tmu for the mucus niche Dietary fiber composition can modulate...
  18. Andy

    Routine outcomes and evaluation of an 8-week outpatient multidisciplinary rehabilitative therapy program for FND 2023 Guy et al

    I use a service called Stork, https://www.storkapp.me/main.php, which finds me papers newly published that match certain keywords every day. I would be more than happy not to have to monitor what the FND folk are publishing but I believe that they present a real danger to our patient community...
  19. Andy

    Routine outcomes and evaluation of an 8-week outpatient multidisciplinary rehabilitative therapy program for FND 2023 Guy et al

    "The themes of these sessions included: behavioral activation and gradually increasing activity, managing ‘boom-and-bust’ patterns, goal setting, strategies to overcome worry, managing anxiety, sleep hygiene and fatigue management, communication styles, volunteering, and relapse prevention...
  20. Andy

    Routine outcomes and evaluation of an 8-week outpatient multidisciplinary rehabilitative therapy program for FND 2023 Guy et al

    Looks like possibly another for you @dave30th ? "Functional neurological disorder (FND) refers to genuinely experienced neurological symptoms that cause significant distress or disruption, without evidence of an underlying neurological, psychiatric or other medical explanation [1, 2]. FND has...
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