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We have a thread discussing N-Acetyl-L-cysteine here N-acetyl cysteine (NAC) Reading the posts there, responses to people's open label trialling seem to range from no effect to a small positive effect on ME/CFS symptoms. It does not seem to be a game changer. Google's AI tells me that...

@Medfeb, is the author group considering doing the review anyway, or does the presence of Cochrane employees mean that the author team composition would have to change? I guess Cochrane has delayed things enough that the Larun et al review is the one that forms part of the evidence base...

It's not actually true that there has been no new evidence. The belatedly published Crawley paediatric paper springs to mind Graded exercise therapy compared to activity management for paediatric [CFS/ME]: pragmatic randomized controlled trial, 2024, Gaunt, Crawley et al. That study also...

Tomorrow and Tomorrow...Studies of the Neuropathogenesis of Long COVID - Serena Spudich, MD That presentation on neurological/cognitive symptoms from a Yale team is worth a watch. No remarkable findings yet, and they have looked at a lot of things, but they are clearly working methodically and...

Whoops, yes. Thank you for the replies.

The abstract claims it was a double blinded study. Well, actually it doesn't quite, there's a bit of sleight of hand there The subjects were enrolled in a double blinded trial, yes, it's just that it didn't stay double blinded through to the analysis of the data. I wonder if some of the...

I'm of course wondering if anything like this could be relevant to ME/CFS. This is from the NIH deep phenotyping study of ME/CFS. PASC.

I still haven't read this paper and probably won't get to it today, but I think it could be interesting to read in the light of the MS B cells in the brain idea.

Yes, but it's based only in the people who come to the clinic. It's possible that vaccination is changing the percentage of people who have neurological problems, or severe enough neurological problems that the people go to the effort of getting to this clinic, out of the total who are infected...

Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein-Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis 2016 paper by some of the same authors as this 2024/2025...

I think AI got 'The Interesting Part' a bit wrong or it's incomplete. I think the authors aren't so much saying the EBV infection happens before MS starts (although that is implied because they are suggesting that the EBV infection causes MS). Yes, there is the paradox of universal EBV...

Intrathecal space The area between the spinal cord and the membranes that protect it, also known as the subarachnoid space. This space contains cerebrospinal fluid, which cushions the brain and spinal cord. So, this study looked at serum and cerebrospinal fluid

I think this study doesn't provide proof for the assertion of the title. We can't tell to what extent persistent neurological manifestations are prevented by vaccination by looking at the people who make it to this clinic, apart from being able to say 'vaccination does not completely prevent...

Capsaicin may have important potential for promoting vascular and metabolic health "Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are found not...

Our thread on the RestoreME oxaloacetate trial: RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al Our thread on the Valacyclovir+celecoxib trial protocol: Valacyclovir Plus Celecoxib for Post-Acute Sequelae...

One on oxaloacetate, one on valacyclovir and celecoxib. I think we have criticised both of these trials. I have a fair bit of time for the Bateman Horne Center, but I think a number of the trials that are done there are problematic. It's such a shame, as the Center could be contributing a lot...

Where are the comments @JohnTheJack?

Professor Jonas Kunst has some good comments on LP:

Cortisol levels are radically different depending on what time of day you test (specifically, how long after your usual wake up time and your latest wake up time). And other things seem to affect it such as pain and other stressful events. Cortisol levels also change to match the level of...

So, actually only three had 8 am cortisol levels below the cut-off level. Also, I don't believe an 8 am cortisol level less than 138 mol/l necessarily means that the person is hypocortisolic. As we have discussed elsewhere, cortisol levels vary a lot over a day, and someone who is not working...