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238 people infected with SARS, 33 died. 205 people survived, 2 with pre-existing hypothyroidism excluded Of the 203, 60 met inclusion criteria and agreed to participate, enrolled at 3 months post-discharge So, quite a lot of people did not participate. I suspect that the authors would have...

I'm not sure if the authors understood 'psychosomatic' in the same way that I do. If an endocrinological basis resulting from a disease process accounts for psychosomatic manifestations, are they really psychosomatic manifestations? It all gets quite circular, but I think one bit of semi-solid...

Long covid studies Distinguishing features of Long COVID identified through immune profiling, 2022, Klein, Iwasaki et al This Iwasaki paper has been very influential in promoting the idea of low cortisol in people with Long Covid. A large study Noting @cassava's excellent post on the Iwasaki...

We have a forum thread on that study of isoforms of IFNAR2: Regulation of human interferon signaling by transposon exonization, 2024, Pasquesi et al.

That's a lot of dropouts. e.g 24 participants in the endurance group, of which 10 dropped out for various reasons 20 controls, 6 dropped out

Hydrocortisone studies Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial, 1999, Cleare, Wessely et al 32 participants. The participants' urinary free cortisol levels were normal throughout, although did increase with hydrocortisone. Low-Dose Hydrocortisone for...

An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2011, Jason et al This paper isn't a study, but I just wanted to flag it to show that even people that we might think understand ME/CFS quite well can have some whacky ideas built on this false idea that cortisol is...

Bobbler, sorry. The posting today is about old papers and the point is indeed to critique them, specifically about the idea that there is a solid body of evidence suggesting people with ME/CFS have abnormally low cortisol levels.

With an attitude like that SNT, you would never have been selected for the study. Clearly you have an unwillingness to change ;) (and way too high a risk of making it clear in the assessment that, no, even though the therapist was nice, and tea and biscuits were pleasant, you are not in the...

Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach, 2020, Pednekar et al This one is a thoroughly awful paper, it's hard to say what they found. There does not look to be any differences in cortisol between CFS and healthy control...

Coming back to this: This study measured cortisol levels in blood before and after the 2 months of seated yoga. Cortisol (μg/dL) reference range 3–20 Before 11.5 ± 8.3 After 10.4 ± 6.3 P value 0.552 So, the participants had very normal cortisol before and after the intervention. There was no...

Japanese study of yoga The longitudinal effects of seated isometric yoga on blood biomarkers, autonomic functions, & psychological parameters of [PwCFS], 2019, Oka et al This study measured cortisol levels in blood before and after 2 months of seated yoga (classes and practiced at home, for an...

Cortisol in hair Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome, 2018, Roerink et al This more recent one is from Knoop's team People with CFS and the healthy controls didn't have statistically different cortisol levels in saliva throughout the day or in hair...

Review of early studies The neuroendocrinology of chronic fatigue syndrome, 2003, Cleare Cleare, who was a coauthor of the Roberts paper above, had earlier done this review of the evidence relating to HPA axis dysfunction in CFS. Cleare notes: He must have been disappointed with the outcome...

Forestglip notes about this review:

Abstract Many studies of patients with long-standing chronic fatigue syndrome (CFS) have found alterations to the hypothalamo-pituitary-adrenal (HPA) axis, including mild hypocortisolism, heightened negative feedback and blunted responses to challenge. However, recent prospective studies of...

Abstract Chronic fatigue syndrome (CFS) is a common and disabling problem; although most likely of biopsychosocial origin, the nature of the pathophysiological components remains unclear. There has been a wealth of interest in the endocrinology of this condition, which will be reviewed in this...

The thread I mentioned: How to write a good introduction for an ME/CFS paper?

You got it into the BMJ, congratulations. I assume it is then easier to get your subsequent papers into that journal? Formulaic but accurate is fine by me. @Ravn had some good comments somewhere, arising from some discussion about a recent paper from Ponting's team. We concluded that short is...

I've started jotting down my thoughts and summaries of forum analyses of papers relevant to the 'cortisol in ME/CFS' question here: Cortisol levels in ME/CFS