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Although the abstract says 14, there were only 10 PASC participants. Edit: I think there is an error in the abstract. Table 1 suggests that there were 10 PASC participants and 14 controls. They then note that they weren't able to place an arterial line in 2 of the 10 people, so they only got...

So, a radioactive molecule that binds with TSPO, which is a marker of macrophage and microglia activation. The scanning then allowed 3D modelling of where in the brain the radioactive molecule showed up. The researchers also took samples of arterial blood to measure the uptake of the...

Could be worth checking out those STROBE guidelines some time. N-PASC cohort: Non-hospitalised Covid-19 infection; lasting neurological symptoms including brain fog for at least 6 months and still present at teh time of scanning. Controls: people from the same monitoring program, prior to the...

The next stage of the project is discussed here: Request for Steering Group members to guide a study on online connections of people with ME/CFS and their offline lives

Given the title of the study is 'how people with ME/CFS use the internet', the conclusion, while sympathetic, seems way too narrow. The internet is not just a source of social support. As @Wonko noted on a related thread, we order food and other things we need. Much like other people use the...

And this seems to be the next stage of the study: Request for Steering Group members to guide a study on online connections of people with ME/CFS and their offline lives

This seems to be the resulting paper (published before the protocol): A systematic scoping review of how people with ME/CFS use the internet, 2023, Shortland

We've created a new symptom discussion thread and have moved the costochondritis discussion there. Costochondritis and rib pain

This section seems to me to be a useful introduction to the topic Table 1 is a list of recent ME/CFS studies classifying big data. It is noticeable how small most of the samples are. The importance of validating the findings is stressed, by holding back a portion of the data for the...

This section has some nice content. I would have liked to see some discussion here about issues specific to ME/CFS that might affect the quality of analysis, as these things are questions we often have about studies and would be useful for new researchers coming into the field. So, perhaps...

A number of us have recognised that it is hard on students to be subjected to public criticism and have tried with this team and others to establish ways for informed patients to provide private feedback before a paper is published. I personally spend time providing private feedback on studies...

There are two different things - the assumed trigger and the collection of symptoms. People can meet ME/CFS criteria after a range of triggers, e.g. post-Q fever ME/CFS; post-EBV ME/CFS; post-SARS-1 ME/CFS; Post-COVID-19 ME/CFS. It's often useful to note the trigger, but ME/CFS is the syndrome...

I agree re the lack of good data. I had a bout of costochondritis for maybe a couple of months some time in the first couple of years after ME/CFS onset. But it looks as though costochondritis is fairly common in the general population. Maybe there is something about hours slumped in bed, or...

Reference 29 is Kavyani B, Lidbury BA, Schloeffel R, Fisher PR, Missailidis D, Annesley SJ, et al. Could the kynurenine pathway be the key missing piece of myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) complex puzzle? Cell Mol Life Sci. 2022;79(8):412. That was a bad paper. We...

There are some good points made e.g. The fluctuation of symptoms and therefore 'omics measurements New technologies such as wearables, home testing, better quicker analysis I don't think pacing is a treatment strategy and nor is support of various sorts. These are management strategies...

Reference #18 is A Treatise on the Principles and Practice of Medicine. Designed for the Use of practitioners and students of Medicine. Atlanta Med Surg J. 1867! I don't think it is helpful suggesting that ME/CFS is such an exception from other diseases. Think of sickle cell anaemia - it has...

I am skeptical about the concept of precision medicine when applied to ME/CFS right now. It works in oncology because clinicians have moved beyond 'cancer' to knowing specific types of cancer and how to treat them. And there is information about how people with specific genes respond to...

I don't believe that there are laboratory tests of even some utility in positively diagnosing ME/CFS, never mind 'definitive'. Again, the authors don't seem to have recognised that long Covid is simply the existence of new persistent symptoms after a Covid-19 infection. If someone meets the...

Introduction I'm continuing to get the feeling that the text is just a bit 'off'; it's not tight. This seems to at once be saying things that are vaguely obvious but are also unevidenced. In some respects, doesn't every chronic illness evolve and perpetuate from a combination of biological and...

But I'm not clear what the word 'complex' is saying there - 1. that it's difficult to work out the cause, or 2. that there are many factors contributing to the disease (including possibly psychological ones), or 3. that the disease has many interacting parts, or 4. that there are lots of...