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Thanks MIJ and SNT This is a paper from mostly a University of Kentucky team, with varied backgrounds but a substantial focus on muscle biology. NIH funding They appear to have started with the idea that there is something in the blood of people with PASC that causes mitochondrial dysfunction...

Which again goes to the problem of 'is that exercise test enough to cause PEM or general deterioration, which would be the reasons why activity would reduce?'. The people with (ME)/CFS who volunteer for these studies are not put off by the prospect of 8 minutes or so of cycling, because they...

That's a manipulative survey. Shame on them, when they know that the patient group they serve has been harmed by manipulative surveys.

Article on the research In particular, I note this "The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss."

Link - open access In mice Venkatramana D. Krishna1, Allison Chang2, Holly Korthas3, Susanna R. Var4, Davis M. Seelig5, Walter C. Low2,4*, Ling Li2,3* and Maxim C. -J. Cheeran1* Minnesota team Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is...

Post moved to USA - Mayo clinic - review of a doctor there

We have a new petition update today: Thanks to our supporters Thank you to the 11,300 people supporting the campaign from 76 countries. Thank you also to The Grace Charity for M.E. for adding their support to this campaign. We now have 76 organisations calling for the 2019 review to be...

I know that people can and do learn new things, and I don't expect people's expertise to only be defined by a qualification they gained years ago. But, I think Gladwell's PhD topic and subsequent promotion of TENS says a lot about the way he thinks. The evidence for the effectiveness of TENS is...

I see from @Sly Saint's post on another thread here, that AfME has acknowledged S4ME discussion in a revision of another document. But that document still has problems, so it's almost worse, to be listened to and yet our points mostly ignored. We've been heard, our name is now on the document...

Is there any way we can get someone in AfME to read this thread and respond? You would think that an organisation dedicated to advocating for ME/CFS would see the forum as a useful window onto how their initiatives land with people with ME/CFS and would be monitoring it. Failing a proactive...

Welcome to the forum @jnmaciuch. Looks like you are going to fit right in. I hadn't seen this before, taken directly from the PACE Participant Manual: You write very well. I think a paper examining the harms of the CBM beyond physical harm would be useful. Just some of the interesting points:

I appreciate that the authors thought this was a topic worthy of working on, and I also appreciate some of their recommendations. But, there are too many substantial omissions to make the results credible. The model they have used is incredibly simplistic - it would not be terribly hard to...

To reiterate - the costs do not include losses caused by long Covid beyond six months! The analysis completely ignores the lifetime loss of productivity that a substantial proportion of people who develop Long Covid likely face.

That's an interesting point - that the WHO's recommendations about vaccination didn't consider a possible lower risk of Long Covid. They note that Australia also didn't consider Long Covid in making a decision about immunisation. Not considering the risk of Long Covid with re-infections seems...

If they want to get into claiming results that aren't statistically significant, they might want to talk about the mean D-dimer increasing in those who did the physical training. That didn't make it into the abstract. Increased d-dimer can be indicative of problems in the coagulation system...

How can the authors write that as the conclusion of the abstract, having just told us that: there was no significant decrease in IL-6 or fibrinogen, and presumably also no significant change in the other two molecules tested (ACE-2 and D-dimer). there was no significant difference in quality of...

Typos - e.g. two in the first paragraph of the Introduction This idea that a patient writes a "care plan", and then finds a health professional to sign off on it - it's nonsense. The process of trying to get a health professional to sign a wishlist written by the patient is likely to be...

The authors recognise that the monitoring period was too short. This study was not a terrible start to the use of activity monitoring to better understand ME/CFS. It was a start. What is terrible is that, 25 years later, we really don't have much more of an understanding about what is going...

They are noting that the average activity decreased in the second half of the post-exercise week for the CFS participants. But, that the CFS participants were active for more hours, resulting in similar total daytime activity to that in the first week. And then they conclude that "the delayed...