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OK, I'll have a go. I can't comment on the credibility of the hypothesis - for me to unpick that would take a lot of time. For what it is worth: My folate levels are unremarkable, not elevated as this team suggest many people with hypermobility are (and I would qualify as 'hyper mobile'). The...

That's the same 14 April Sky news article that TiredSam linked above It gives the appearance of an unedited media release e.g.

A trial protocol for a study of tVNS on post-cancer fatigue: Effect of transcutaneous auricular vagal nerve stimulation on the fatigue syndrome in patients with gastrointestinal cancers — FATIVA: a randomized

Discussion thread on this treatment here: Vagus Nerve Stimulation The tragus (part if the ear) as a place for the stimulation is questionable - when I last looked, it seemed likely that the vagal nerve did not enervate the tragus. The sham treatment in this study protocol seems a bit weak - no...

Is there anything stopping a group of us writing a new review for Cochrane? What would be the steps?

For those of us getting confused by all the 'm's' in front of RNA and DNA: messenger RNA (mRNA) - a single strand of RNA. Gene > transcript of the gene is the mRNA > the mRNA is read by a ribosome to make a protein (transfer RNA (tRNA) bring the Amino acids to make the proteins) microRNA...

I understand that that idea has been resisted due to the desire to have a fairly ethnically consistent sample to cut out unrelated genetic variation. (I still think that sampling places like Australia, New Zealand and Canada wouldn't disrupt that too much - and it would presumably be possible...

From a recent paper specifically looking at people with post-Covid exertion intolerance, a finding of increased numbers of CD169+ macrophages: But, this latest study might indicate that a persisting increase in CD169+ macrophages is a general post-Covid effect. It's great that Maureen Hanson's...

Background on CD169+ from Functions of CD169 positive macrophages in human diseases (Review), 2021

It's great that this study was very selective with the group with post-acute covid-19 symptoms i.e. They didn't just use a group of people with Long Covid, with that vaguely defined as at least one ongoing symptom, which could be anything as diverse as loss of smell, poorer lung function and...

New abstract Myalgic encephalomyelitis, ME, previously also known as chronic fatigue syndrome (CFS) is a heterogeneous, debilitating syndrome of unknown etiology responsible for long-lasting disability in millions of patients worldwide. The most well-known symptom of ME is post-exertional...

More on the consultation process for the "Examining the Working Definition for Long COVID" here: USA: 'Examining the Working Definition for Long COVID' consultation 2023

The study reports that 59% of depressed people had their depression improve in at least a minor way, over the 4 years after talking therapies. And yet, 53% of depressed adults who receive no treatment have been reported as showing improvement within 12 months. I haven't checked out that...

That headline is true - people have linked talking therapies with cardiovascular disease. However, it's also very misleading - it makes only just a tiny bit more sense than "Cheese linked with the composition of the moon". There were no controls - everyone in the 636,955 person sample...

We have an In Memory thread here Dr Jonathan Kerr

While I have reservations about NCNED (and awe at their ongoing ability to pull in funding), I think the Australia Rickettsial Research Laboratory and specifically the main person there, Professor Stephen Graves, is good, scientifically and for their concern about people with ME/CFS. It's a bit...

A 2023 study failed to replicate the findings of the 2021 study: Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia, 2023, Sara Cavaria et al

One more thing: This study failed to replicate a 2021 study on the transfer of pain behaviour to mice via IgG from people with fibromyalgia. That study made quite a splash at the time. Forum thread on that study here: Passive transfer of fibromyalgia symptoms from patients to mice, 2021...

Well, I didn't see even an acknowledgement of the potential problem of human neutrophils in mice in the paper. The charts seem to make a good story, but there is a credibility problem.

Ha. I wondered whether human neutrophils would work in mice, it seemed a bit amazing. I haven't read the discussion of this paper yet (or much of the Method - which is at the end of the paper. Surely, they will address that issue, it's pretty fundamental. Not to minimise the impact of these...