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For sure, it's a bad sign when the introduction makes claims that aren't supported by the references given for them. But, I think I said just the other day, it seems to happen in most papers. It's the last section that I find most interesting. The healthy mice were treated identically, except...

Neutrophils Derived from Patients with Fibromyalgia Syndrome Induce Mechanical Hypersensitivity in Mice The researchers then took neutrophils from people diagnosed with fibromyalgia (9) and healthy controls (5), and injected them into new healthy mice (4 mice for each person). So, this is the...

Neutrophils Derived from Mice with Chronic Widespread Pain Infiltrate Sensory Ganglia Somata? Plural of soma - the body of the neuron (and a few other cell types). So, they found neutrophils had infiltrated the somata of the dorsal root ganglion in the mice that had had two injections of...

I'm not surprised. I can't recall any reliable reports of elevated cytokines in ME/CFS or fibromyalgia, although perhaps there are some. I'm not sure, has it been known before that neutrophils are associated with peripheral pain? And that removing them seems to prevent the pain? That bit...

Circulating Neutrophils Are Essential for the Development of Hypersensitivity in a Mouse Model of Chronic Widespread Pain So, now the researchers wanted to find out what is causing this sensitivity of the nerves. This works was done in 4 control and 4 primed mice. They transferred blood...

In vivo electrophysiology The mice were anaesthetised,and the spinal cord exposed. Then the researchers applied stimuli (pressure and heat/cold) to the hind paw and measured the evoked activity of neurons. These measurements were done by an experimenter blind to which sort of mouse they were...

Persistent Hypersensitivity in a Mouse Model of Chronic Widespread Pain So, a model of chronic widespread pain? What this seems to be is two injections of an acute inflammatory stimulus into muscle, 4 days apart - thus creating the 'Primed Mice' The 'Control Mice' only had one injection. 7...

Some background information from the introduction that sets up their study - could be worth checking the references out: (that's not about neutrophils - but might worth reading about. Have we heard about mitochondrial transfer?) (Neutrophils are a type of white blood cell, as are...

I get that. Most providers of knowledge content pay the people who produce content (e.g. journalists) and those who improve it and check it (editors and content checkers). Scientists producing papers shouldn't have to pay to get their results out into the world, and possibly should actually be...

Sounds a little like Paul Garner's superpower in overcoming Long Covid within a year. I think it might be the BPS superpower of attributing things that would happen anyway to one's own moral superiority.

Thanks for identifying some key areas to look at @Ravn. I did make some comments a while back, but I should go in and give it another go. It's a bit of a random approach to consultation, but I expect the content will be considered, at the very least by political parties wanting to get a sense...

Yes. I guess I was thinking of this as a potential source of misdiagnoses. So, there may not be enough people with this particular problem misdiagnosed as ME/CFS to get about the threshold for significance. But, DecodeME might find a handful of people with the functionally impaired variants...

That trial is the Castro-Marrero one; forum thread here: Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related QoL in ... ME/CFS, 2021, Castro-Marrero et al.']Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and...

It's baked in, this inability to differentiate association with causation.

CoQ10 - Coenzyme Q10 Here's our CoQ10 discussion thread. I'm not aware of any credible trial identifying CoQ10 as useful in ME/CFS and do know of some that suggest that it probably isn't. But, interesting to see that defects in the COQ2 gene are associated with that condition 'familial...

One thing I'm not sure about is the difference between lactate in peripheral blood from fingerpricks and lactate as measured by a catheter as per that study I linked to above. Is there any reason that the different sources/methods might tell a different story? There is that one 2022 study...

If ever anyone comes across health-related research recently approved in Aotearoa New Zealand that you think is unethical, perhaps due to risks to participants or due to its lack of scientific merit, please do send me a message.

I was a member of the same college! I can confirm, members do not all agree with Sharpe. Not sure about fellows.

It sounds as though elderly and other very vulnerable people were shielded early on, so a lot of the people who did get Covid-19 early on would have been young people at low risk of death. And a lot of the people who both got covid-19 early on and were tested probably were young medical...

Forum thread here for this Ref #7: Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome, 2022, de Boer et al It found higher lactate in people with post-acute COVID-19, even with no co-morbidities, using catheters during...