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Just on the lactate question: Figure 1B. From the left: PASC with comorbidities PASC without comorbidities Metabolic syndrome Healthy, moderately active Measured using a catheter during CPET.

In that Resilience diagram, "Behavioural Activation" features prominently - helping with 'good routines', 'purposeful activity', 'keep active and involved'. Then there's Mindfulness; Problem Solving; Managing worry; good sleep habits; contacting'Talkplus'. I'm pretty sure that CBT fits all...

Symptoms like this? Symptoms that sound a lot like a lot of Long Covid? I agree that you'd think it would have been noticed and raised questions. But... I haven't read this paper, or looked at the references that the authors cite to support their claim of

It is really gratifying to see such co-ordinated and generally well-conceived push-back against the CLoCK Study. Well done to the people involved. I hope that they will keep pushing.

One of the biggest problems is that the CLoCK study is going to say 'oh, these symptoms are very common. Look, the children who weren't infected with Covid (as evidenced by a negative test) have just the same sort of symptoms. So, Long Covid isn't a thing.' So, again, there's trouble with a...

What a mess of buck-passing. I don't understand why the research ethics committee that approved the research (Yorkshire/Humber/South Yorkshire REC) isn't answering the letter of complaint. I'm not sure what 'sponsor' means, but it sounds a lot like someone marking their own homework. How can...

Yes, particularly in a story about mothers and daughters. 'what's gone on in your environment' makes it too easy to start blaming mothers.

Very sad. It's terrible seeing young people having their lives so limited. It looks as though ANZMEs were involved in this article; good on them. The only awkward notes in the article are Professor Tate's quotes (above) that leave the door unnecessarily wide open for the interpretation of...

Yes, it's not surprising that reported fatigue improved in both the treatment and placebo - partly that's what the ambiguity of the CFQ is there for, and partly all the participants would have had an expectation of an effect. There was an improvement on average of 5.2 points on the CFQ scale...

Thread on the published paper: Efficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised

We have a discussion thread on this topic - here: Metabolic acidosis - high anion gap

My lactate levels were normal, and the response to exercise in terms of lactate was normal. I didn't find anything unusual at all. I have had an anion gap test twice. Both times it was highish. It's one of the issues with my lab testing that I have marked as being odd. It was a reason why I...

Good on them for proposing ways of testing their hypothesis. There is some reporting of preliminary and sometimes questionable research findings in support of their hypothesis, but I can't recall the last paper I saw that didn't do that. For what it is worth, I bought a home lactate meter and...

Here are notes on other things: A power point slide on the premise for testing cryotherapy included a reference to Kulis et al 2017 which found that cryotherapy induced a decrease in the elasticity of erythrocytes. But, I thought, if anything we had a problem with the rigidity of our red blood...

I made it to the webinar, I woke up nearly in time although missed the first five minutes. Most of the webinar was filled up with a presentation by the researcher. The host, Rochelle Joslyn, asked some questions, but little information came out in response. Other than Rochelle, I was the only...

A reminder that this is coming up later today/tomorrow, depending on your time zone 1 pm New York time 14 April More info here: Combination of whole body cryotherapy with static stretching ... reduces fatigue and improves functioning of the [ANS] in CFS, 2022, Kujawski et al You need to...

More on that exogenous corticosteroid possibility: Is there a safe and effective way to wean patients off long-term glucocorticoids?, 2020 I haven't looked closely to see if that is likely to be true, but it does sound concerning.

So, a large proportion of people with FM have CFS. And higher levels of cortisol are characteristic of FM (and, by extension, CFS). But wait - higher cortisol? Wasn't it supposed to be lower cortisol? Or lower cortisol before breakfast? Or something? People are so sure these conditions...

It's an issue I've been giving quite a bit of thought to, but this is the first time I have seen it in the media. Here in my country, the plan to staff our health system seems to involve a very large percentage of immigrants. That's quite a big imposition on the countries that produce those...