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Item 2 made no sense to me, so coming back to this. RER at anaerobic threshold is, by definition, 1. So those numbers that are reported cannot be at anaerobic threshold. There's no issue of putting in effort at the anaerobic threshold - it's a metabolic thing. An RER over 1.1 at VO2max...

Obviously the Minister doesn't know much about LC. But I do sort of sympathise with her not wanting to make a commitment on a radio programme, and especially not wanting to be seen to endorse a particular researcher. There is a process for evaluating research for govt funding, and it shouldn't...

Yeah, when 12 decent controls can't be mustered up, it really doesn't send the message of 'We understand that this a a major global social and economic catastrophe that also potentially has relevance to a whole range of devastating post-infectious illnesses, and we are working tirelessly to...

Six patients were reinfected during the study period. There are more women in the Long covid group, and the average age is different, so these factors could be affecting metabolite differences in small samples. Interesting comment on the possible impact of Covid treatments on glucose...

Currently, a preprint. The abstract is a bit confusing; it's hard to know what is happening in various subsets. 15 hospitalised Covid survivors from one hospital; 33 hospitalised survivors from another hospital. 18 of these people reported no persistent symptoms. 17 reported 1 to 4 persistent...

Fair point, the participants should have been given a chance to provide feedback on the article. But at least these authors recognised that the lack of feedback was a problem. That's rare enough that I thought it was a step in the right direction.

This finding about antibody secreting cells looks nice and straightforward. Black healthy controls on the left, pink ME/CFS on the right. Numbers of antibody-secreting B cells as a percentage of all B cells. This is for cells in the CSF; there wasn't the same finding in the blood. The total...

I thought this was a really nice paper, easy to read, and clever science. Whether it will pan out, I don't know, but it looks like a good lead to follow. How wonderful if this produces a cure/really effective treatment for Parkinsons. I imagine the scientists who were being sniggered about...

There was that work being done to diagnose people with Parkinsons by smell. If their guts are producing hydrogen sulphide, that might explain why it's possible. Regarding the magnetite !

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full Introduction: The aggregation of the neuronal protein alpha-synuclein (alpha-syn) is a key feature in the pathology of Parkinson’s disease (PD). Alpha-syn aggregation has been suggested to be induced in the gut cells by...

I think there might be something wrong within the paper too. The discussion suggests that reduced effector molecule expression in memory T cells is correlated with the severity of cognitive deficits and quality of life measures. So, lower levels of CD45RA-CD27- was correlated with worse...

I don't think that news release is right, is it? I don't think there were lower levels of CD4+ and CD8+ T cells. Rather, there were lower levels of effector memory cells (CD45RA−CD27−cells) as subsets of the CD4+ and CD8+ cells. The y axis in these charts is the percentage of CD4+ helper T...

Blood tests Sounds as though all of these were unremarkable. Symptom assessment Just noting that the NIH didn't bother to assess for PEM, or compliance with ME/CFS criteria. Cerebrospinal fluid pleocytosis - increased white blood cell count. Oligo-clonal bands, indicating antibodies...

An alternative way to phrase that finding would be 'Just over half of the participants had a history of depression/anxiety before COVID-19. Also, this is a highly selected sample, so the symptom mix may be more reflective of what the trial participant selectors were looking for, than of people...

I'm not sure I'm following. These authors actually said 'address social risk factors like food security'. They included quotes where the participants talked about living in food deserts, about how hard it was to get good food due to the combination of the limited services in their...

Some data out for the NIH ME/CFS study too - discussed here: USA: National Institutes of Health (NIH) intramural ME/CFS study

Thank you Brian! A quick summary: HC = healthy controls ME = ME/CFS Figures in brackets are probably SD unless otherwise specified I've bolded the ones that look statistically interesting (hard to tell in some cases) Some interesting lack of differences e.g. in CRP, a marker of inflammation...

The OMF webpage about this or related research by this team gives some information e.g.

Conference abstract Introduction: Mechanisms underlying exercise and orthostatic intolerance in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have been uncovered by invasive cardiopulmonary exercise testing (iCPET) and autonomic function testing (AFT), but the relationships between...

This is exactly why I get a bit annoyed with people who try to suggest that people with ME/CFS need a huge amount of education by health professionals in pacing or energy management. In reality, it's mostly muddling through, tweaking things as necessary. Muddling through successfully...