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[Crossposted] I've got to stop, I'll have to come back to this. The last figure is Figure 3 which gives the amount of IL-1b produced by microglia cells exposed to the exosomes from healthy and ME/CFS people. These are the pooled samples. This study isn't feeling very solid. There might be...

So, serum for an unknown number of people with ME/CFS before and after exercise and serum for an unknown number of healthy controls, presumably just before exercise. The order in these charts is Healthy Controls: ME/CFS before exercise: ME/CFS after exercise Figure 1b shows that total exosome...

Theoharis C Theoharides; Irene Tsilioni - Tufts University school of Medicine Benjamin Natelson - Icahn School of /medicine at Mt Sinai Funded in part by the Ramsay award from the Solve Me/CFS Foundation The writing is accessible. The small size of the study is noted as a limitation. The...

Rapid responses to the paper are possible, if anyone has the energy and inclination to quote some of the papers that have found significant numbers of Long covid people meet ME/CFS criteria. We have a tag "lc=me/cfs" that can be put on papers that assess LC patients against ME/CFS criteria...

Yes, that's interesting. It's a problem. Reading about that recent COFFI meeting where the BPS people were wanting to attack these ideas of extremely low recovery rates in ME/CFS, I do think we need to improve in our educational materials and things like the CCC. It's a more complicated story...

Oh, yes, that would be great. I could definitely see David on the international literary event circuit too - I reckon there'd be a lot of interest.

Are they seriously going to cold call people, targeting migrants who may or may not have good German language skills, with the aim of getting 2400 people to tell them about their bowel function? And quiz them about their health literacy, their personal experiences with their IBS, including the...

"Persistent somatic symptoms - parameters of risk" PSS-POR :whistle:

Nice to see the donation from Iceland. I hadn't realised that Norway has those islands so far north until I saw them highlighted with mainland Norway on the donation map. Svalbard - I'd heard of it. There's the Svalbard Global Seed Vault there. That's exciting @dave30th. Is there something...

Based on prospective studies of post-infection illness, there is a declining curve of people still sick over the two years following onset. Typically, from memory, it's around 10% of people infected with certain trigger diseases who still have symptoms that significant affect daily life at 6...

2023 workshop. I'm sure a great time was had by all. e.g. Item 2: Why do more women suffer from PVS? These topics probably provide some clues on future research papers. e.g. Item 3: It is often said that attitudes to the illness may influence outcomes. Is it possible to measure these in...

New thread for the fact sheet here: World ME Alliance Fact Sheet on ME

I think it's pretty good in most respects. Some common problems: I don't know why they don't use ME/CFS, which seems to be the standard term. And, that damn word "complex", which means whatever you want it to mean. There's no acknowledgement that recovery rates are high initially - there's at...

Yes, this study looks ok to me too, written well, designed well, clear and consistent benefits. Iranian research. A supplier is mentioned as providing the melatonin and placebo tablets, but there are no conflicts of interest declared by the researchers. Even if they did have a connection with...

Oh, I think they got that memo, and the one after about using surveys that don't actually measure what the title says. And the one about gaslighting patients so that they do indeed believe that their personality or childhood is faulty prior to administering the survey. And the one about how...

There's quite a lot to this study, a lot of adjustments and assumptions that need to be understood when interpreting the findings. I mean, I think it's been done well, but it's surprisingly complicated. Re the hospitalised controls: Re the type of ME/CFS patients: They use a washout period...

Figure 2 gives the long list of psychological variables that can be correlated with the illnesses they see as psychogenic, and then pointed to as causal, and targets for intervention. These people have had long enough to prove their theories, at least with respect to ME/CFS, and for most of...

I'm baffled too. Putting aside the insurance companies and CBT app sellers who have a financial reason to minimise the problem, why do these people believe the BPS idea that us just being more positive, and setting goals will make the difference? Is it that it makes them feel safe, because...

It's interesting to note that 49/55 of the PCS-ME/CFS are female, but only 35/51 of the PCS are female. They only assessed hand grip in females and had a lot of drop outs at follow-up, only 37 PCS-ME/CFS and 25 PSC. So, the results are interesting, but also messy. There's quite a bit in...