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It's good that the article is open access, and that it's possible to read the feedback of reviewers. The study was partly funded by a patient group, although I bear in mind the previous studies by Castro-Marrero that were funded by a supplement manufacturer. The study was of a good size (250...

Yes, there's so many questions. It even seems possible that low levels of MBL might be a protective response to intra-cellular parasites The ambiguous role of mannose-binding lectin (MBL) in human immunity

There was a similar finding about low levels of MBL in a 2015 study: Frequent IgG subclass and mannose binding lectin deficiency in patients with CFS, 2015, Guenther, Scheibenbogen et al

An interesting paper on ME/CFS immunology from a team based at the Medical University of Vienna: Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Lutz et al

Interesting to find a relatively high incidence of MBL deficiency in these two samples of ME/CFS patients. It now seems to have been replicated here: Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Lutz et...

https://www.sciencedirect.com/science/article/abs/pii/S0198885915004656 S. Guenther, M. Loebel, A. Mooslechner, M. Knops, L. Hanitsch, P. Grabowski, K. Wittke, C. Meisel, N. Unterwalder, H. Volka, Carmen Scheibenbogen Abstract Chronic fatigue syndrome (CFS) is a severe disease characterized by...

This recent paper looking at Long Covid patients (91% had "PEM") Preprint: Chronic COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS) following the first pandemic wave in Germany.., Kedor et al, 2021 found:

Regarding the mannose-binding lectin levels: It is not clear from that the paper or the supplementary tables if the 32.1% of the ME/CFS patients had MBL levels less than 50 ng/ml. The normal range given in paper's supplementary table 1 is '<300 ng/ml' - possibly it was meant to be >300...

I think it's of note that Lex Medica, the source of that information I quoted above, is an organisation that facilitates medical professionals being expert witnesses in court cases. It is not completely clear to me who Patrick Hill has worked for in those cases. I also didn't notice the first...

The proposal was copied in this post up thread.

I assumed it was Patrick Hill, the person who signed the write-up about the proposal. And it seems it is him: edit to add link: https://lexmedica.co.uk/dr-patrick-hill-2/ Bath, Bristol... Pain management, CBT...

Yay, a little bit of rationality. A better outcome than I could have hoped. It almost has me wanting to join twitter just to like the tweets. :)

@Brian Hughes :thumbup:

Perfectionism is discussed on the thread linked below, and others that you will find by clicking on the 'perfectionism' tag on this thread A person-centred test of multidimensional perfectionism and health in people with chronic fatigue syndrome versus healthy controls, 2021, Sirois et al

No need. If you convince the general public and the GPs that people have only got Long Covid because of their personality flaws, the patients will very quickly get the message. :confused:

I'm still struggling to comprehend how these people think. It's suggested in the short video that the science for predicting Long Covid from psychological/personality attributes is all sorted, and mostly there just needs to be a publicity campaign to tell everyone. I mean, I don't think...

No one gets to miss out on the wisdom of the BPS. An (mis)information campaign - just what we need.

"4. Campaign theme - Development and promotion of valid psychological screening to predict chronicity, post COVID-19 infection. Member network Division of Health Psychology, Division of Clinical Psychology A cognitive-behavioural model, first described by Surawy et al in 1995 has been...

Wow, that is quite something.

It's interesting that they felt that there was not enough data to produce an evidence-based guideline. But they'll present some recommendations anyway, with the Methods section summarised as 'We had a meeting and we decided this seems about right'. They go on to note that their etiological...