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It's possible higher doses are needed. From Phoenix Rising:

FYI, in October 2023, the journal added this disclaimer to the top of the page:

I'm not sure the exercise intolerance in CoQ10 deficiency is very similar to PEM though. From another case report: Other than that, I don't see many papers giving much detail of what exactly they mean by "exercise intolerance" in this condition. But it makes me think it might be worth...

This discusses CoQ10 deficiency disorder. I'm posting because it mentions exercise intolerance and cognitive dysfunction as symptoms multiple times, as well as because CoQ10 is an oft mentioned supplement in the ME/CFS world. Abstract Background: Primary deficiency of coenzyme Q10 deficiency-4...

Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress, 07 July 2022

https://www.michaeljfox.org/news/national-plan-end-parkinsons-act-makes-progress-congress S.4851 - National Plan to End Parkinson’s Act

"The paper studied the non-disabled and then extrapolated the result to the disabled" would be more accurate as "The paper studied people people diagnosed with GWI who walk a lot and extrapolated to people with GWI who do not/can not walk a lot." Disability can come in a million different...

The primary and secondary outcomes show they will be measuring levels of 10 different chemicals, but why wouldn't they also include symptoms? I assume the initial visit questionnaire will ask about symptoms. Then they'll "repeat the baseline assessments". I don't know if that includes the...

Hmm, if they already spend 10% of their waking hours (~1.6 hours) doing "moderate-vigorous activity", it's not surprising that the exercise test wasn't very bad for them.

Did they only test symptoms within one hour after exertion? So they missed any PEM that takes longer than one hour to appear? @SNT Gatchaman Do you have the charts or any text about the "physical activity behavior"?

I do rideshare (Uber and Lyft) and food delivery (Uber Eats and Doordash). It doesn't pay much hourly, but I can work as much as I want, and take as much time off as I want, and they are basically the least exertion jobs I could think of that pay enough to live on (I'm bad with physical and...

What was the point? Are they trying to show that not all people with gulf war illness have PEM? What does this mean: So some people in the study had PEM, but if you take the results of the group on average, then the average person in the group didn't? Is that was "group-level risk" means...

I think that would be really useful, but I don't think so, and I'm guessing it's probably not even possible with the API. But I asked on the HitCounters extension talk page. I'm pretty sure that's what MEpedia uses for PopularPages and it seems to be the only page view tracking extension available.

Yeah, it feels very powerful and is fun. I can imagine it will be very useful to the discovery of biomarkers and treatments in all sorts of conditions. I wish I was super rich and could hire a team of ML experts to make some of my (what I think are promising, like the above) ideas a reality.

Oh! Ability to sing on key. When I'm in a good period, I'm not winning any awards but it's mostly the correct pitch. When I'm in a rough patch, I feel bad for anyone within earshot.

For now it's just a vague idea. I'm not really equipped to do intense projects and I'm pretty much a beginner in these technologies. But I'll try to send him an email to see if he has any feedback. Thanks!

That's interesting - an EEG was the best method for detecting fatigue in drivers. 100% accurate. I wonder how to get me one of those... Also, in the blog I wrote about how making one label for fatigue per day, but taking lots of photos, could confuse the model if there's lots of variability...

Also, if this worked well, it could possibly be used as a PEM alerter, kind of like a dog that alerts if a seizure is about to happen. Maybe something like if you are doing too much, then the rate your expression is changing to fatigued is high, and you can have something that alerts if the...

Yep, I'm totally hitting backspace much more frequently when I'm very fatigued. This seems potentially useful. A keylogger that captures each button press and the time between. It might return something like this: P - 7 ms D - 5 ms BACKSPACE - 3 ms U - 6 ms P - 5 ms P - 2 ms Y - 4 ms Though...

I considered using a general emotion detection model, but I'm worried that what it's trained to detect won't capture the correct details for ME/CFS-like fatigue. Like day to day, these could be extremely tiny differences in a few pixels around one area of the face, while the emotions it was...