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Possibility of inaccurate representation of the patient's symptoms So, bearing in mind that the authors appear to have a conflict of interest and that their paper almost certainly had to have sign off by their hospital's legal team, what evidence is there in the paper against this being a case...

I think it's worth looking at this paper for a bit, because on the face of it, FND sounds quite plausible. The case study subject reports paralysis, but tests of sensation and reflexes show that there is still nerve function, and a raised hand drop test shows that she can control the limb...

On the studies undertaken to find (latent) enteroviruses in people with ME/CFS, with a conclusion that more and better studies are needed: I think it's reasonable to hypothesise that persistent enteroviruses can cause ME/CFS, and to investigate the hypothesis. I think it's less reasonable to...

Indeed. I've had the same thoughts. I certainly hope that there is some worthwhile strategy to explain this. The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review, Hanson et al (2021) There is this 2021 review paper which...

I am (desperately) hoping that AI has taken over Maureen Hanson's identity to churn out this essay.

I'm pretty surprised by this paper, I'm really not sure what to make of it. What's with the dismissal of the idea that ME/CFS occurs after Ross River Fever and Q fever? Why the unwillingness to see people with post-Covid symptoms meeting the ME/CFS criteria as having ME/CFS? But an acceptance...

:) Of that we can only dream. (oh, apart from DecodeME)

Some background information about RER, it's probably over-simplifying things: https://web.cortland.edu/buckenmeyerp/fall2004/labrvalue.html This is the machine that reports the RER and oxygen use and CO2 production in everyday settings: I agree that the concept of this study was excellent...

I wonder how many of these 23 studies had suitable controls. Studies without active controls can't tell us if these interventions (in populations where the majority will be improving with time) are of any use. And yet:

One of the authors is Sarah Tyson @sarahtyson. The assessments were done in 2021, and the study found that even people with severe ME/CFS were mostly able to use monitoring equipment without problems. I'm therefore not understanding Sarah's conclusion, expressed on the forum earlier this year...

and all of the usual misinformed easy opinions about ME and FND

Yes. Just to reiterate this, here's some of the text from the webpage I linked to upthread that I thought set it out well: Not that I'm suggesting that the authors here were trying to suggest more about their data than was warranted. It's just - please give us the scatter plots. That's...

Also, with the recent WASF3 study in mind, we need a similar sort of study on the effect of standard processing and storage on other types of cells.

So, keeping storage times to an absolute minimum, reducing variation in this and detailed reporting. Also, EDTA tubes were recommended. I think this study raises some important questions for biobanks. I think they need to be very selective about what sort of analyses they supply stored blood...

Thanks @Andy, this is a really important issue for all of the studies that have been done using the Seahorse analyser. We've been calling for information on this. The paper describes the Seahorse analysis in a readable way and gives clear definitions of the parameters reported It is good to...

(I like your avatar @chillier, is that just new? Nudibranchs are glorious.)

Going a bit further on in the paper WASF3 Suppresses Mitochondrial Respiration So, this is still with the cells of patient S1. The expression of the WASF3 gene was reduced (using shRNA - a short hairpinRNA). The authors say that this The higher black line is the increased oxygen consumption...

My response to that cannot be written here. But it really shows that these people have no idea what they are talking about. Relax? Tired? I know we've said it all before, but it's the sheer arrogance these people have, to think that we have not tried to ignore the symptoms and keep going...

Were the participants required to exercise in the metabolic room?

I had to search to find out what the error bars are for Figure 5b (that's the WASF3 levels from the NIH ME/CFS study participants). I eventually found a reference to one of the charts in the Supplementary Information to Standard Error. In my experience, standard errors on charts are not a good...