Search results

EBV in salivary glands - Walitt. Moving forward with a tissue procurement protocol to look for antigens, and investigate the EBV persistence idea. Other inflammatory drugs - Nath. Sure, just need to trial them in a clinical trial. Nath - No evidence that there are transmissible viruses. So...

Walitt - on the order of the parts of the diagram. 'It was an hypothesis generating programme - the diagram seems to be the most compelling story.' Komaroff concludes that it is a brain disease caused by immune activation. Nath agrees. Paper shows huge amounts of immune dysfunction. (not sure...

Questions: Effort preference playing an important role in other disorders such as MS and Parkinsons- Walitt. Yes, it does. Further studies will bring more understanding How can NINDS get more funding for treatment trials. Nath. He doesn't manage funding so he can't really answer. Federal...

Cognitive therapy for brain fog. 'Functional disorders' appeared on slide. Suggestion that women have B cell activation and men have T cell activation There was a list of mainly immunological drugs that might be useful. There is a Long Covid IgG/IgM crossover trial Nath has finished...

Dr Nath is now discussing the symptoms of Long Covid. He's talking about the Long Covid study. So far he is not discussing the NIH ME/CFS study. He's talking about other studies suggesting neuroinflammation after Covid-19 and damage to the BBB. Suggestion that there is a problem switching...

Walitt is still going over a whole lot of history of ME/CFS and various post-infectious illnesses. Nothing very objectionable, but, if we wanted a history of ME/CFS, we wouldn't go to Walitt. It is one way to minimise discussion of the NIH ME/CFS study.

Elizabeth Unger read the update Dolphin posted above in post #303. There's a lot there, it's worth a read. I get the impression that the CDC and Elizabeth Unger personally is making an effort. A transcript of the whole call will be posted. Next up Walitt and Nath.

it's on now

Sure, but we never see such well-powered and definitive studies out of NCNED. They have received a lot of the Australian ME/CFS funding, probably more than any other group. From here, it's hard to know if the funds are being used well. I do think that it's questionable to keep doing small...

Fantastic news - Solve M.E. have agreed to be a supporting organisation, signing the original open letter. It is great to have this large US charity on board with the campaign. (Actually they agreed to support the campaign at the end of last year, but, in the blur of a family health emergency...

That's interesting, I didn't know that. (Edit, like Eddie, I find it a bit hard to believe that's true for e.g. an active adult or a growing child.) In the Results section, there is this about participant selection and source of the blood samples: There is reference to a methods section, but...

Some pedantry about the introduction: I thought people were moving on from Long Covid being one thing, to recognise that there are quite a few reasons for people to have persistent symptoms after Covid-19, with ME/CFS being just one of them. But, these authors aren't recognising that. It...

Yes. I often present my reactions as I read, noting questions that I would like to see answered later on. To read the whole report, making notes as I go and then writing up a succinct synopsis would take me much longer, and I might not ever get to post anything. Think of our process as a...

That's an interesting article. Both NZ and Australia have moved to the new viral genetics based HPV test (screening for cervical cancer), with the kits allowing easy in-home testing. For sure, people with ME/CFS who are home bound should be able to access these kits if they want them. The...

A number of posts have been moved to A general thread on the PACE trial! These posts cover topics such as: AfME's role in the PACE trial, and its role, as well as the MEA's role, in later criticism of it the nature of early criticism of the PACE trial concerns about the selection of...

I'm trying to think what happens as a result of both physical and mental exertion (as well as immunological exertion). One thing seems to be lipid mobilisation. Effects of mental stress on lipolysis in humans, 1992 I can imagine lipid mobilisation potentially having some negative downstream...

A reminder from the mod team that this thread is about Paul Garner. We have split off some of the posts about the PACE trial. If you wish to continue discussing aspects of the PACE trial, you can do so on this thread: A general thread on the PACE trial!

There is though the possibility that one latent or integrated pathogen is reinvigorated (sorry, I can't think of the right term) when someone is battling one of many possible infections (or even some other stressor). So, perhaps a herpes virus that most people acquire in childhood, or a HERV...

Yes, that was mentioned in the media item I saw. A brain tumour had been suspected, he had scans and nothing was found. Link to an article about the rugby player, Billy Guyton. The article says that tau proteins are markers of the damage. In that case, there are ways to test the living brain...

Thread on the symposium where the NIH investigators presented their findings 2024: NIH National Institutes of Health - ME/CFS Symposium on Intramural study - 2 May (There are links to other threads related to the NIH ME/CFS Intramural study in the first post of this thread.)