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The study is certainly drawing a long bow. In theory, reduced reaction times as part of Long Covid might be playing a part, but the investigators report a real time association between road deaths and Covid-19 cases. So, it's more likely to be people who are sick with acute Covid-19, maybe...

I've said it before, but I would really like to see a proteomic study with multiple CPETs (more than 2, maybe 5, one per day ) done in people with relatively mild ME/CFS (with very careful control of activity levels before and between the tests, and frequent testing of blood and reaction time...

Perhaps it is just a difference in how PEM is defined, but I think this sentence indicates that there is still not a clear understanding of what PEM is. For me, PEM is not something I experienced after exercise when healthy, not even briefly. The experience that I term PEM is when the only...

There is a lot of overlap between the two cohorts. The arteriolar/venular (width) ratio (AVR) shows the best separation, with a very good P value. But, still a lot of overlap. The association with narrower retinal arterioles became non-significant "after adjustment" for confounders. I'm not...

These measures have been used in heart disease research and seem to be credible as measures of endothelial dysfunction. 41 PCS 204 healthy controls - SARS CoV-2 naive - which is a shame. Healthy post Covid-19 patients would have been better The Canadian Consensus Criteria were used to identify...

I'd missed this paper:

I'm not clear on whether at least the first part of the study this protocol is for has been completed and published. I think maybe it has.

Agitation - really? Or just warranted concern that your whole life has been turned upside down and the medical profession and everyone you know keep wittering on about 'looking on the bright side', 'going for a walk' and 'sleep hygiene'? Yeah, nah. ME/CFS does not equal fatigue. Ref 25 is from...

Cherry-picked participants; cherry-picked outcomes. Another study in a long line of studies, this one with a hopelessly small sample size. And still there is no convincing case made for the treatment. Katherine Jongsma, Bri Susanna Darboh, Sasha Davis & Emily MacKillop It's worth...

Jin-Seok Lee ab, Wakiro Sato c, Chang-Gue Son ab a Research Center for CFS/ME, Daejeon Hospital of Daejeon University, Daejeon, Republic of Korea b Institute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea c Department of Immunology, National Center of...

This paper follows on from an earlier literature review by the first author and other co-authors that had a lot of problems. Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?, 2022, Kavyani I have yet to have a...

The study is discussed more here: UK:ME Association funds research for a new clinical assessment toolkit in NHS ME/CFS specialist services, 2023 Members have criticised the lack of attention to objective measures in a clinical assessment toolkit that aims to quantify disability, track progress...

My experience with one adult and two young people going through the assessment and monitoring stages for ME/CFS is that medical records are totally inadequate as a representation of symptoms and disease progression for adult patients, and even worse than totally inadequate for young patients.

If I had invented the green toes drug and really wanted to know if it worked, I'd arrange to have a control cohort. I'd have people in both cohorts have their toes covered with an adhesive bandage that showed if it was tampered with, and have them video themselves each time they take the pill...

I like this idea a lot. I think it is relevant to not just the UK, but wherever there are ME/CFS/LC services. In my career, I had some involvement with organisation certification schemes. They made a difference to the quality of the organisations and also helped consumers identify which...

The 2009 Light study found I don't know how the 2009 Light study determined gene expression for TLR-4 - by expression on PBMCs or by soluble TLR4. This 2023 study found:

Utterly horrifying. Kasia Kozlowska 1,2,3,* , Olivia Schollar-Root 1, Blanche Savage 1,4, Clare Hawkes 1, Catherine Chudleigh 1,4, Jyoti Raghunandan 1, Stephen Scher 5,6 and Helene Helgeland 7 1. Department of Psychological Medicine, The Children’s Hospital at Westmead, Westmead, NSW 2145...