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The problem is the diagnostic criteria is not specific enough. I don't think all ME/CFS cases are the same but there may be large subgroups with common etiology. In hindsight, it is easy for us to say that the person I knew who fought hard for years to get heart surgery which cured their...

There aren't many, I'd 5% at most. I've just been ill for too long so I've known too many people.

Yes, I mixed up CNS with neurological in general. The issue isn't merely the injury, but the response to that injury. Eg nerve sensitisation. The brain receiving out of wack autonomic or fatigue signals can have explanatory power. The fact that ME/CFS like syndromes are common post-GBS should...

I have known more than a few people who have recovered. They've all had quite different experiences and more than a few of them believe their experiences are not generalisable to other ME/CFS patients.

Not necessarily, unless the injury is severe. SFN in particular is hard to see without a biopsy. But imaging of peripheral nerve/dorsal root ganglion is almost never done in ME/CFS. And the reply to JE, few tissues have actually been investigated in ME/Patients

I can tell you haven't done a true maximal CPET because it is absolutely the muscles being unable to continue/the heart reaching its limits that causes cessation of CPETs. Treadmill CPETs are not conducted with ME/CFS patients due to the risk of falling. I literally had my vision black out when...

Type I (or II) interferons don't signal fatigue directly, but besides immune system mediated effects, it does lead to other changes including sensitisation of afferent nerves in both the dorsal horn and dorsal root (which can be due to it being involved in the tissue repair process)...

The general worldview of the medical practitioner makes a huge difference - myself and a family member have had severe vaccine related side effects (causing risk of death and lifelong disability) - GBS (Guillain Barre Syndrome, an autoimmune peripheral nerve disease) in my case and GBS AND...

Thinking about arfgef/rabgap1l and immunological effects. An Updated View of the Importance of Vesicular Trafficking and Transport and Their Role in Immune-Mediated Diseases: Potential Therapeutic Interventions https://pmc.ncbi.nlm.nih.gov/articles/PMC9230090/ Restriction factor screening...

The view of stress causing disease is highly prevalent. There is a discussion on Reddit, r/guillainbarre that stress is the cause of the big increase in prevalence of GBS in Gaza - rather than a large increase in GBS triggering infections. And many people believe that it is pregnancy itself that...

DCC is much more interesting gene than the others (as it is involved in peripheral nerve regeneration), but it was only found in the replication analysis "Lifelines and UKB Biobank cases" not the main study. I wonder why an association was found in other samples/studies but not the main one...

That is my hunch too, as unpopular as this may be.

Doesn't this strain the meaning of "MS onset"? Diagnosis is not the same as onset. Patients had MS related symptoms years before that diagnosis, maybe that should be considered the real onset? It seems like contradictory reasoning..

This is interesting, but it contradicts it being "FND" if it is caused by https://en.wikipedia.org/wiki/Cortical_spreading_depression

Yes, heart rate variability is affected by numerous things and is a very POOR/non-specific marker of anything in particular and especially psychological well-being. HRV decreases during exercise, so that means exercise is bad, right? RIGHT? https://pmc.ncbi.nlm.nih.gov/articles/PMC9439241/

Any sort of oral/nasal vaccine tends to have very poor efficacy in humans. The hype about 'mucosal vaccines' tends to not result in real world efficacy but there might be some value using intramuscular vaccine first and an oral/nasal vaccine a month or two later as the boost.

I don't think it's a problem with adenosine specifically, but that sensing adenosine is part of the fatigue sensing apparatus of the brain and plays a role in neurovascular coupling, analogous to the afferents that stimulate fatigue sensing muscle afferents.

The Scientific reports journal is a far cry from Nature... I don't mind the lack of blinding so much as the combination of lack of blinding with no meaningful objective outcomes.

That seems wrong. Changes in diagnosis rates amongst PoC and those of poor socioeconomic class is not the same as a change in characteristics of those affected.

Yes, our proprioception of limbs can be fooled because it is a predictive system, but our pain systems cannot because they are not predictive (and it makes no sense that they would be predictive).