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"retrospective cross-sectional study" (of an online convenience sample, no less)... Which are only ever of "suggestive" quality...

This is just an abstract, it is unclear if/when there will be a published manuscript.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257016 The study is interesting, but I'm not sure they're measuring what the think they're measuring - they claim they can't tell the difference between IgM and IgG for example. The discussion also has a lot of nonsense about...

"Patient centred"... Yet no patients were ever asked what their preferences were.

It is certainly overly simplistic, giving high statistical weight to nonspecific factors, rather than specific factors.

Another quote.

"Longer spoken response"... Give me a break!

Perfusion typically refers to blood flow across a capillary bed, rather than cross membrane transport of molecules. But caherins are involved in cell adhesion and hypothetically, abnormalities could disrupt the normal function of cellular junctions. The following articles discuss various...

Strong Inference Certain systematic methods of scientific thinking may produce much more rapid progress than others. John R. Platt Science, October 1964. https://pubmed.ncbi.nlm.nih.gov/17739513/ http://pages.cs.wisc.edu/~markhill/science64_strong_inference.pdf Personal comment: the more...

This one certainly gets mentioned a lot... While I agree with the conclusion "Full recovery from untreated CFS is rare.", a major limitation is the lack of long-term followup of most studies.

Given the absence of other excessive inflammation markers in circulation in most patients, I wonder about the other functions C1Q has (non classical complement cascade), and why it might be of high abundance in the first place... Emerging and novel functions of complement protein C1q...

Yes, but the claim of "50%" is not actually based on reasonable quality research. It is the severe persistent symptoms (>3 months) that we care about and there are no prospective studies that follow community based (not hospital based) prospective cohorts reporting severity of symptoms after 3...

Plenty of people live highly stressful lives and don't develop LongCovid (example certain prime ministers and presidents). Plenty of people live low stress lives and still develop LongCovid or other post-viral conditions. Men like this Fossli Jensen simply don't care about epidemiological...

The immunity may be better, but the overall risk profile is worse...

When I say deconditioned, I obviously mean compared to some prior basis. This may seem surprising, but doing a large quantity of activity ('exercise') doesn't necessarily maintain (or increase fitness). It is the intensity of that activity (activities that reach a high heart rate and high...

Someone who does 7000 steps per day can still be deconditioned, because fitness is about intensity, not number of steps.

It is because there is substantial overlap between the blood volume of ME/CFS patients and sedentary controls. To the point that reduced blood volume alone cannot be considered a causative factor.

Oh dear!

Don't see any risk of problems? The outcomes aren't what the patient chooses, they are negotiated with the "multidisciplinary team" (see Turner-Stokes' guide), which leaves in a strong risk of the choice of outcomes being coerced by the specialist. "Yes doctor/specialist, you know best"...

I wish they would focus on severity of symptoms and impact on daily life, rather than merely listing number of symptoms.