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  1. Snow Leopard

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    I'm saying the reason why patients would reject a referral to MIND is because the treatments will be ineffective. This is what a patient would say to a medical practitioner for example, rather than I don't want that referral because "ME is a physical illness".
  2. Snow Leopard

    Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19, 2021, Jesuthasan et al

    We knew in mid 2020 that it was BS. The problem is mildly increased cytokine levels is somehow being equated to a "storm", when this is nonsense when compared to the true cytokine release syndrome where levels are extremely high. Study of critically ill patients finds no cases...
  3. Snow Leopard

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    Isn't that an an example of a secondary argument - that patients will only be offered irrelevant/ineffective treatments?
  4. Snow Leopard

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    Yes, the primary argument is GET is harmful and ineffective. The 'ME is a physical disease' is merely a secondary corollary from the fact that neither cognitive behavioural therapies nor psychoactive medication is effective. Patients do need to be clearer with our arguments, because 'ME is a...
  5. Snow Leopard

    Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19, 2021, Jesuthasan et al

    With the mention of "cytokine storm" in the abstract (which we know isn't associated with COVID), I am not expecting this one to be terribly enlightening.
  6. Snow Leopard

    Learning to feel tired: A learning trajectory towards chronic fatigue, 2018, Lenaert et al.

    The authors mistakenly assume this means that participants were actually experiencing more fatigue associated symptoms. But an alternative hypothesis is that watching the video clips simply induced response biases.
  7. Snow Leopard

    Learning to feel tired: A learning trajectory towards chronic fatigue, 2018, Lenaert et al.

    Figure 1 contains a literal circular argument - (CS) fatigue causes (CR) fatigue which cases (US) fatigue which apparently feeds back and causes (CS) fatigue. This explains the rationale of Graded Exercise Therapy (GET), which is a type of Cognitive Behavioural Therapy. The idea is that there...
  8. Snow Leopard

    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    It shows you they take claims by researchers on faith, rather than actually looking at whether the methodology is meaningful.
  9. Snow Leopard

    Persistent Exertional Intolerance after COVID-19: Insights from Invasive Cardiopulmonary Exercise Testing, 2021, Singh, Systrom et al

    Drops of 27% in 3 weeks can only occur in highly trained athletes, not people within a standard deviation of the mean. It is important not to compare apples to oranges, a point which seems to have escaped those authors. Note that reference 26 is a 1968 editorial which doesn't present primary...
  10. Snow Leopard

    UK: Priority Setting Partnership: Medically Not Yet Explained Symptoms - 10 top priorities published July 2022

    If you strip away the fancy graphics, the study is of low quality as it is a cross-sectional convenience study based entirely on questionnaires, so there is a high rate of participation bias, response bias. A better methodology would be to measure patterns of symptoms over time (prospectively)...
  11. Snow Leopard

    Covid-19 vaccination experiences

    Six weeks is neither here nor there. Three weeks will lead to a lower antibody titre, but higher quality antibodies, since it extends the activity of the B-cell germinal centres in the lymph. Eight weeks or longer will lead to maximal antibody titre, but at a potential cost of antibody variety...
  12. Snow Leopard

    Covid-19 vaccination experiences

    I don't know what they mean by "life-changing" side effects, but I assume most of those are still acute, rather than chronic. It is higher than most vaccines, though some (non-universally used) vaccines like typhoid can cause a similar rate of similar acute side effects.
  13. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    Likely in a few months when they actually have some supply. This is speculation, but I expect Novavax to pivot at some stage to suggest that it is safer for young adults and children, compared to the other vaccines. If it is genuinely safer, it is likely to be the option used for under 12s.
  14. Snow Leopard

    Exertional intolerance and dyspnea with preserved lung function: an emerging long COVID phenotype?, 2021, Lam et al

    The 6 minute walking test is not maximal (or reliant on a ramped workrate protocol), so it is fairly meaningless. They are claiming these people are suffering from dyspnea, but without fatigue or pulmonary impairment - but the latter claim is not based on prospective data and is therefore...
  15. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    Here is some excerpts from her recent research: The Female Predominant Persistent Immune Dysregulation of the Post COVID Syndrome: A Cohort Study https://www.medrxiv.org/content/10.1101/2021.05.25.21257820v1.full-text PROMIS Scales for Assessment of Persistent Post-COVID Symptoms: A Cross...
  16. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    The Tweeter is simply incorrect. 77% of the population with one dose means they have not reached "herd immunity" for R0>5. The current numbers in Iceland are similar to those predicted (in a previous post) by the Grattan institute.
  17. Snow Leopard

    Questioning Biomedicine’s Privileging of Disease and Measurability, 2021, Kroll

    Another twenty diagnoses, maybe!?! Okay, I cleaned up the references to avoid confusion...
  18. Snow Leopard

    PEM induced only by sensory/cognitive exertion - what does it indicate about the pathophysiology of ME?

    I have a headache in the upper front of my head 100% of the time, but it is deeper, I wouldn't describe it as a sore forehead (front of head above eyes) at all. This pain gets much worse when mentally drained. It is quite likely this is related to some sort of blood flow or cerebral perfusion...
  19. Snow Leopard

    Questioning Biomedicine’s Privileging of Disease and Measurability, 2021, Kroll

    Aside: a more personal article by the author: https://hekint.org/2021/06/07/seeking-medicalization-chronic-illness-without-diagnosed-disease/
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