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  1. Snow Leopard

    Questioning Biomedicine’s Privileging of Disease and Measurability, 2021, Kroll

    That's a nice start. Yeah, no. Try talking to some patients first, before saying such misleading things about our reasons for refusing treatments or our needs. What patients what is treatments that work to help them recover their functioning, so that they can better meet their human needs...
  2. Snow Leopard

    Covid-19 vaccination experiences

    My main concern is about the reliability of the tests that are used. There is still a great deal of variation between tests and samples from the same individual.
  3. Snow Leopard

    ME/CFS services in the United Kingdom

    Yes. They've just cut & pasted the stuff about chronic pain and added ME/CFS. They seem to have no sensitivity to the idea that illness can be severely limiting such that human needs cannot be met without additional support.
  4. Snow Leopard

    Discovery and Identification of fatigue-Related Biomarkers in Human Saliva, Xu, 2008.

    The sensitivity/specify for each of the proteins was fairly weak so I can't conclude much from this study. Yes, we can pool the results together, but until the algorithm is tested on another cohort, we don't actually know how accurate it is.
  5. Snow Leopard

    PEM induced only by sensory/cognitive exertion - what does it indicate about the pathophysiology of ME?

    Same. I do get prolonged (several days) cognitive fatigue (and headache worsening) from cognitive activity, but I don't get PEM related muscle issues or flu symptoms from it, whereas I do get those symptoms from physical stressors. For me, sensory sensitivity (and OI) result from PEM, rather...
  6. Snow Leopard

    Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?, 2021, Mantovani et al

    Exactly. Unless the test was performed prospectively (before illness) for comparison, claims that there is no reduction in performance are not valid.
  7. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    I doubt it is much different. Delta is slightly better at getting into and out of cells once it is already in your body. It isn't any better at surviving on surfaces.
  8. Snow Leopard

    Individual physiological and mitochondrial responses during 12 weeks of intensified exercise, 2021, Jacques et al

    In the olden days they were worried about taking up too much space in the journal. These days that does not matter at all and researchers that don't provide basic data visualisations are simply inferior scientists...
  9. Snow Leopard

    Individual physiological and mitochondrial responses during 12 weeks of intensified exercise, 2021, Jacques et al

    All of the data was pooled into means, so we don't know. The SDs didn't really increase, so probably not in most participants, which is to be expected of healthy people.
  10. Snow Leopard

    Individual physiological and mitochondrial responses during 12 weeks of intensified exercise, 2021, Jacques et al

    Notably, of the ~8% increase in VO2Peak, most of it was in the first 4 weeks. The lack of a clear effect on mitochondrial or muscle fibre composition should not be too surprising. VO2Peak is rate-limited by the cardiovascular system - it is about how much oxygen can be delivered to the muscles...
  11. Snow Leopard

    News from Australia

    From the ABC article mentioned above. Funny about that!
  12. Snow Leopard

    Covid-19 vaccines and vaccinations

    As I posted in another thread: R effective = Rz (reduction in transmission of breakthrough cases * proportion vaccinated + proportion unvaccinated)*(proportion vaccinated (1-Vaccine efficacy against symptoms) + proportion unvaccinated) Rz is the effective R for various social restrictions...
  13. Snow Leopard

    Covid-19 vaccines and vaccinations

    I don't think those figures are credible. They are not the result of test-negative case control studies like the Canadian and UK data. There are suggestions that those figures may be artifacts due to some errors and lack of matching exposure rates with suitable controls. At 6 months...
  14. Snow Leopard

    Long covid after breakthrough infection

    Viral loads at the start of an infection is not a sufficient proxy for transmissibility, given that those viral loads may diminish much faster since the immune system has already been primed, and hence be infectious for a shorter period of time. Only a community based (whole population) contact...
  15. Snow Leopard

    Long covid after breakthrough infection

    I hope that isn't true! Most of the models governments have been using have been based on (this is a random transmission model which works on the large scale, but not so accurate on the small scale): R effective = Rz (reduction in transmission of breakthrough cases * proportion vaccinated +...
  16. Snow Leopard

    Patients with Persistent Polyclonal B-Cell Lymphocytosis Share the Symptomatic Criteria of Systemic Exertion Intolerance Disease, 2021, Morizot et al

    This either suggests common pathology, or a lack of specificity of the SEID criteria, or poor operationalisation of the SEID criteria.
  17. Snow Leopard

    Long covid after breakthrough infection

    I think vaccinations against variants will be necessary in the future. It might not be annually, but biennially (every two years).
  18. Snow Leopard

    Long covid after breakthrough infection

    Mutations are a stochastic process, so more vaccinations means less mutations due to reduction in cases! Vaccines can apply 'selection pressures' that can lead to vaccine escape mutations, but the virus seems to be becoming more virulent just fine without the help of vaccines.
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