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  1. InitialConditions

    Open New York, USA: Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (NAC ME/CFS)

    Honestly, this seems like a waste of money to me. We would know by now if NAC had a significant effect on ME symptoms in a significant number of patients.
  2. InitialConditions

    CBT for CFS Therapist Manual PAEDIATRIC CFS TEAM, ROYAL UNITED HOSPITAL, BATH, UK Loades, M.E. & Starbuck, J. | 2020

    It would be good for someone to catalogue these NHS materials. Does anyone do this or know of anyone who does?
  3. InitialConditions

    Woken by horrible bone pain (?) in leg last night

    Thanks. My vitamin D level is fine, and is actually probably quite high at the moment because I'm supplementing with a 5,000 UI dose.
  4. InitialConditions

    Woken by horrible bone pain (?) in leg last night

    I don't take any medication really, and never knowingly had any problems with sugar or salt levels. But who knows.
  5. InitialConditions

    Woken by horrible bone pain (?) in leg last night

    Pain is not a huge issue for me. But last night I was awoken - must have been around 3 am - by a horrible deep ache in my right leg. It almost felt like bone pain. I think this has occurred a few times before in the past. I managed to get back to sleep after 20 mintues or so. Has anyone...
  6. InitialConditions

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    This is the paper the article is based on https://link.springer.com/article/10.1007/s11420-020-09777-1 Considerations for Return to Exercise Following Mild-to-Moderate COVID-19 in the Recreational Athlete "The COVID-19 pandemic has resulted in significant morbidity and mortality around the...
  7. InitialConditions

    Polish zoo to give elephants cannabis extract for stress relief

    I know one solution that would instantly lower their stress levels.
  8. InitialConditions

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    I've seen several in the MESpine Facebook group, some of whom have got worse. A common theme is for them to blame the lack of progress or worsening on something else - usually tethered cord.
  9. InitialConditions

    Mitochondria May Hold Keys to Anxiety and Mental Health

    https://www.quantamagazine.org/mitochondria-may-hold-keys-to-anxiety-and-mental-health-20200810/ Research hints that the energy-generating organelles of cells may play a surprisingly pivotal role in mediating anxiety and depression.
  10. InitialConditions

    No Benefit of 3 Commonly Used Medications in MS Fatigue

    It needs to be stated again that medicine really doesn't understand fatigue, nor know how to treat it.
  11. InitialConditions

    A Low Glutamate Diet Improves Cognitive Functioning in Veterans with Gulf War Illness, 2020, Kirkland et al.

    Yeah, I wondered how you could separate out the effects of removing high-glutamate foods from the effects of removing other ingredients and compounds also found in those foods.
  12. InitialConditions

    A Low Glutamate Diet Improves Cognitive Functioning in Veterans with Gulf War Illness, 2020, Kirkland et al.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859338/ This is an n=1 case study, but this patient had IBS, fibro, and OCD (which I suffer with) and improved on a low glutamate diet. Edit. Just noticed one of the authors is an author of the study above. Hmm.
  13. InitialConditions

    Accurate and Objective Determination of ME/CFS Disease Severity with a Wearable Sensor. Palombo et al. 2020

    There's a myth in our community that we'd all recover under the right circumstances - avoiding PEM, stressors, being able to rest at all times when needed.
  14. InitialConditions

    New draft NICE guidelines for chronic pain emphasises exercise, CBT and acupuncture over medication

    Of course, the largest of many elephants in the room is perhaps cannabis, which barely gets a look in due to lack of evidence (read lack of studies).
  15. InitialConditions

    (ME) outbreaks can be modelled as an infectious disease: a mathematical reconsideration of the Royal Free Epidemic of 1955, 2020, Waters et al

    Do we know any more on the authors, apart from the details given at the end of the article?
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