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Tearing down societal barriers to being able to work is a good thing, but you have to be pretty tone deaf or ignorant if that’s what you propose as a solution for something like post covid ME/CFS.

Ah, Xitter always confuses me with their ordering. So we could be looking at a Rituximab style placebo? No way to tell, really

I wish he included an ‘this is obviously just an unblinded n=1’ disclaimer. And ‘chronic disease’ could mean anything.

I wonder how HRV would correlate with PEM if you never get close to your VT1, e.g. low intensity physical activities over a long period of time. Surely that could also trigger PEM?

I believe they did some live measurements of nerves and lots of probing and insertion of instruments. There are some diagrams in the figures.

I believe these are the questions of SSD-12. No wonder they correlate with anxiety etc. ————— Q1_I think my somatic symptoms are due to a serious illness Q2_I am very concerned about my health Q3_My health concerns hinder me in daily life Q4_I am convinced my symptoms are serious Q5_My...

Several criticisms of the BPS model can be distinguished: it is vague and not testable (5, 44–46); too general and eclectic (46, 47); a mere juxtaposition of causal factors without an integrative framework (48, 49); and not methodological and inapplicable in daily practice (22, 45, 50)...

THF-beta was mentioned here (I have no idea about the relevance): https://www.s4me.info/threads/tgf%CE%B2-links-ebv-to-multisystem-inflammatory-syndrome-in-children-2025-goetzke-et-al.43084/

They’ll just spin it as another win for the gut-brain-axis and neuroplasticity.

If we could get them to stop exploring disproven hypotheses it would be a good start. Putting more money into bad research will probably only do harm.

Risking harm from an infection in order to decrease the likelihood of harm from an infection seems kind of backwards to me.

It seems like they might be trying to gently shut down the lunacy of ‘immunity debt’.

Do they speculate about the reasons for the increase in severity?

Anything on what the clinic is supposed to do for the patients?

No mention of bias and no methodological assessment of the certainty of the evidence. Lots of bias towards BPS explanations. Only one study with objective sleep tracking. I don’t think this review is worth much..

I just want to clarify my current stance on this: I agree with them that ‘burnout’ is an unnecessary diagnosis. It’s broad, vague and just another way to dismiss patients. But I do not, in any way, agree with their reasoning about e.g. unhelpful beliefs and the proposed treatments. They are...

According to MEpedia, this book has a whole chapter on ME/CFS:

25 = REGAIN, unblinded and subjetive outcomes 46 = study on elderly hospitalised patients. ‘Blinding’ was not telling the patients if they were in the low (40-50 % of max HR) or moderate (50-70 % of max HR) intensity group, or the control group that did nothing in particular. In my opinion...

The quality of RCTs was assessed using Cochrane Collaboration’s tool (RoB-2 tool)29 for risk of bias. This tool includes five domains: randomization process, deviations from intended interventions, missing outcome data, measurement of outcomes, and selection of reported results. Each domain was...

It’s so much worse. I believe they might have been recruited from her phd thesis, which had major flaws. I’ve posted about it on the thread about the thesis, this is my AI-aided summary: