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Study, but only abstract (line-breaks added) https://pubmed.ncbi.nlm.nih.gov/40080546/ Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson's Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determined a...

So you got worse again 3 months after the infection? I’ve spoke to a few of people that reported the same. Some eventually recovered, others did not.

My pure speculation is that the differences were derived from biomarkers that were correlated with symptoms presentation, and not just based on symptom presentation like we would have to do for PEM. For me instant was like delayed PEM. I get less of it now because I rarely push too far beyond...

Figure 2 Post-exertional malaise scaling example based on a qualitative interview. CPET, cardiopulmonary exercise test. Figure 3 Overlay of post-exertional malaise, physical fatigue and composite visual analogue scales for healthy volunteers. CPET, cardiopulmonary exercise test; PEM...

Description Presenter Steven J. Smith, MD, will speak for a short time with a few slides and then there will a long Q&A/discussion session. Dr. Smith is now retired and publishing research, but in his long career as an interventional radiologist, he noticed that many of his Pelvic Congestion...

I don’t think that’s feasible without a biomarker that we have casually linked to the variability in symptoms.

The thing is that you say that it’s always delayed. Someone else will say that it can be instant. And another person will say that it can be accumulated. All based on their personal experiences and beliefs about how their body works. And because nobody can say that the others are wrong - and...

It’s certainly not redundant! It’s very valuable to get to check the logic - and I have no guarantee of being right just because it makes sense to me. If someone else asks ‘what about this’, we can both say that it has already been addressed. That process is what gives the end results its value.

I’ll add some brief comments to explain my wording and current opinion (which might be wrong or inaccurate). Bolding is mine. I believe ‘report’ is essential to include exactly because we don’t have definitive studies. We can’t risk giving off the impression that the descriptions of PEM are...

This is why it’s so difficult to learn to judge your threshold, because the symptoms and warning signs can change.

Yeah, I think this is what PEM is. And then we could possibly give reports of how different people experience it. But very briefly, like ‘often delayed’, ‘from stimuli’, etc

It’s the approach of pretending that reality goes away or changes if we ignore it.

Those people are at a much higher level of functioning, and it might be that PEM behaves differently at that point. We’ve seen some studies that find differences between mild/moderate and severe (or worse). It might be that whatever PEM is, it behaves differently in bodies with an inherently...

@Evergreen thank you for putting so much relevant info together like that. I agree with this interpretation.

The article says this: I guess she didn’t get the note about how the psychosomatic medicine is the recent and final paradigm shift away from mind body dualism. Again with the art thing. I’m so happy we have someone like her that can intuitively understand what’s wrong with everyone!

Does anyone know if the guidelines mention ME/CFS or even PVF?

‘It fits better with my completely unevidenced, speculative, opportunistic, and philosophical view of humans.’

She might want to start by considering if she’s also wrong. There’s plenty of bad info on LC out there, but that doesn’t make her right.

Table 1. Pre- and Posttest Survey Questions In addition to knowledge, student attitudes towards ME/CFS changed after viewing the videos and slides. For example, qualitative responses indicated that after experiencing this activity, students were more aware of the definition of PEM. In the...

Those figures make my eyes bleed.. It looks like something a 6 year old would make in their first day at the computer lab in 1997.